冠状动脉
医学
冠状动脉粥样硬化
心肌桥
心脏病学
内科学
血管造影
计算机断层血管造影
心肌桥
冠状动脉造影
计算机断层摄影术
动脉
放射科
冠状动脉疾病
心肌梗塞
作者
Andreas A. Giannopoulos,Basil Bolt,Dominik C. Benz,Michael Messerli,Elia von Felten,Dimitri Patriki,Cathérine Gebhard,Aju P. Pazhenkottil,Christoph Gräni,Philipp A. Kaufmann,Ronny R. Buechel,Oliver Gaemperli
出处
期刊:Angiology
[SAGE]
日期:2023-02-14
卷期号:75 (4): 367-374
标识
DOI:10.1177/00033197231156637
摘要
Myocardial bridging (MB) is a segment of coronary arteries with an intramural course, typically spared from atherosclerosis, while the adjacent proximal segment is reported to be atherosclerosis-prone, a phenomenon contributed to local endothelial shear stress (ESS). We aimed to describe the ESS milieu in coronaries with MBs combining coronary computed tomography angiography with computational fluid dynamics and to investigate the association of atherosclerosis presence proximal to MBs with hemorheological characteristics. Patients ( n = 36) were identified and 36 arteries with MBs (11 deep and 25 superficial) were analyzed. ESS did not fluctuate 5 mm proximally to MBs vs 5 mm within MBs (0.94 vs 1.06 Pa, p = .56). There was no difference when comparing ESS in the proximal versus mid versus distal MB segments (1.48 vs 1.37 vs 1.9 Pa, p = ns). In arteries with plaques ( n = 12), no significant ESS variances were observed around the MB entrance, when analyzing all arteries ( p = .81) and irrespective of morphological features of the bridged segment (deep MBs; p = .65, superficial MBs; p = .84). MBs are characterized by homogeneous, atheroprotective ESS, possibly explaining the absence of atherosclerosis within bridged segments. The interplay between ESS and atherosclerosis is potentially not different in arteries with MB compared with arteries without bridges.
科研通智能强力驱动
Strongly Powered by AbleSci AI