肿瘤微环境
免疫系统
衣壳
体内
光热治疗
自愈水凝胶
噬菌体疗法
噬菌体
佐剂
癌症研究
化学
材料科学
生物
免疫学
纳米技术
病毒
生物化学
有机化学
大肠杆菌
生物技术
基因
作者
Xue Dong,Pei Pan,Qiuling Zhang,Jing‐Jie Ye,Xian‐Zheng Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-02-02
卷期号:23 (4): 1219-1228
被引量:17
标识
DOI:10.1021/acs.nanolett.2c04279
摘要
Due to the complexity and heterogeneity in the tumor microenvironment, the efficacy of breast cancer treatment has been significantly impeded. Here, we established a living system using an engineered M13 bacteriophage through chemical cross-linking and biomineralization to remodel the tumor microenvironment. Chemically cross-linking of the engineered bacteriophage gel (M13 Gel) could in situ synthesize photothermal palladium nanoparticles (PdNPs) on the pVIII capsid protein to obtain M13@Pd Gel. In addition, NLG919 was further loaded into a gel to form (M13@Pd/NLG gel) for down-regulating the expression of tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Both in vitro and in vivo studies showed that the M13 bacteriophage served not only as a cargo-loaded device but also as a self-immune adjuvant, which induced the immunogenic death of tumor cells effectively and down-regulated IDO1 expression. Such a bioactive gel system constructed by natural living materials could reverse immunosuppression and significantly improve the anti-breast cancer response.
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