微乳液
肺表面活性物质
增溶
色谱法
化学
药物输送
材料科学
化学工程
纳米技术
工程类
生物化学
作者
Sagar Narendra Ande,Krutika B. Sonone,R.L. Bakal,Prashant V. Ajmire,Harigopal S. Sawarkar
出处
期刊:Research journal of pharmacy and technology
[Diva Enterprises Private Limited]
日期:2022-10-21
卷期号:: 4829-4834
被引量:10
标识
DOI:10.52711/0974-360x.2022.00811
摘要
Microemulsions are one in all the most effective candidates as novel drug delivery system due to their long time period stability, improved drug solubilization with simple preparation and administration. Surfactants and cosurfactants play crucial role to get stable, mild and clinically acceptable microemulsions in their optimized concentration, The main aim of the study to produce an efficient screening approach for the surfactant and cosurfactant selection for the excipients of microemulsion formulation development and to check the consequences of surfactant hydrophilic–lipophilic balance (HLB) as well solubilization stability process in microemulsion. The composition and extent of surfactants and cosurfactants were key variables for physicochemical properties of drug-loaded Microemulsions. The important aspects must be considered for a successful microemulsion process is that the stability of the liquid membrane. This study is an attempt to grasp the mechanism of the effect of the surfactant and chain length of co-surfactants within the microemulsion base formulation stability.
科研通智能强力驱动
Strongly Powered by AbleSci AI