MP05-08 POSSIBLE ROLE OF THE MICROBIOTA IN URINARY STONES: A PROSPECTIVE STUDY TO CORRELATE RADIOLOGICAL DENSITY (HOUNSFIELD UNITS) AND CULTURAL EXAMINATION OF URINARY CALCULI

You have accessJournal of UrologyCME1 Apr 2023MP05-08 POSSIBLE ROLE OF THE MICROBIOTA IN URINARY STONES: A PROSPECTIVE STUDY TO CORRELATE RADIOLOGICAL DENSITY (HOUNSFIELD UNITS) AND CULTURAL EXAMINATION OF URINARY CALCULI Antonio Luigi Pastore, Yazan Al salhi, Andrea Fuschi, Alessia Martoccia, Fabio Maria Valenzi, Alessandro Sciarra, Stefano Salciccia, De Nunzio Cosimo, Andrea Tubaro, Costantino Leonardo, Giorgio Franco, Silvio Scalzo, Paolo Pietro Suraci, Onofrio Antonio Rera, Alice Antonioni, and Antonio Carbone Antonio Luigi PastoreAntonio Luigi Pastore More articles by this author , Yazan Al salhiYazan Al salhi More articles by this author , Andrea FuschiAndrea Fuschi More articles by this author , Alessia MartocciaAlessia Martoccia More articles by this author , Fabio Maria ValenziFabio Maria Valenzi More articles by this author , Alessandro SciarraAlessandro Sciarra More articles by this author , Stefano SalcicciaStefano Salciccia More articles by this author , De Nunzio CosimoDe Nunzio Cosimo More articles by this author , Andrea TubaroAndrea Tubaro More articles by this author , Costantino LeonardoCostantino Leonardo More articles by this author , Giorgio FrancoGiorgio Franco More articles by this author , Silvio ScalzoSilvio Scalzo More articles by this author , Paolo Pietro SuraciPaolo Pietro Suraci More articles by this author , Onofrio Antonio ReraOnofrio Antonio Rera More articles by this author , Alice AntonioniAlice Antonioni More articles by this author , and Antonio CarboneAntonio Carbone More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003216.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of the study is to evaluate a possible correlation between the hardness of the urinary stone expressed in Hounsfield Units and the bacterial contamination by cultural examination of the lithiasic fragments obtained after endoscopic treatment (ureteral lithotripsy and retrograde intrarenal surgery). METHODS: This prospective study investigated patients with unilateral urinary lithiasis (ureteral and / or renal) who underwent endoscopic lithotripsy between January and December 2021. All patients were studied preoperatively with Uro-CT scan, measuring the Hounsfield Units, the number and size of the calculi for each patient. Two lithiasic fragments were extracted at the end of each procedure (one from the core and one from the periphery of the stone) and sent for chemical-physical and cultural examination. RESULTS: Seventy-three patients were enrolled and studied prospectively. 56 submitted to ureteral Holmium Yag Laser lithotripsy and 17 to RIRS. The chemical-physical evaluation showed 92% of the stones made up of calcium oxalate, 4% of calcium phosphate, 2% of uric acid and 2% of various composition. The bacterial analysis of the fragments showed a positive culture in 68% of cases, with positive Staphylococcus Epidermidis in 46% of cases, Proteus Mirabilis in 24%, Escherichia Coli in 23% and 7% with other microorganisms. The correlation between stone core culture and formation HU was statistically significant, with Staphylococcus Epidermidis associated with a mean Hounsfield value of 1234 HU; Proteus Mirabilis with average Hounsfield 872 HU; Escherichia Coli with mean Hounsfield 642 HU (p values <0.0001). The mean radiological density in the negative culture urinary stones was 843 HU. CONCLUSIONS: Our study demonstrates a statistically significant correlation between urinary stone infection and its radiological density (HU). We postulate that the correlation between the stone core isolated microorganism and the calculi hardness (HU) might impact on the treatment choice and results (stone free rate). Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e46 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Antonio Luigi Pastore More articles by this author Yazan Al salhi More articles by this author Andrea Fuschi More articles by this author Alessia Martoccia More articles by this author Fabio Maria Valenzi More articles by this author Alessandro Sciarra More articles by this author Stefano Salciccia More articles by this author De Nunzio Cosimo More articles by this author Andrea Tubaro More articles by this author Costantino Leonardo More articles by this author Giorgio Franco More articles by this author Silvio Scalzo More articles by this author Paolo Pietro Suraci More articles by this author Onofrio Antonio Rera More articles by this author Alice Antonioni More articles by this author Antonio Carbone More articles by this author Expand All Advertisement PDF downloadLoading ...