化学
胰腺癌
癌症研究
程序性细胞死亡
癌症
细胞凋亡
癌细胞
生物化学
纳米技术
内科学
医学
材料科学
生物
作者
Bo Peng,Gang Chen,Yahui Li,Hao Zhang,Jianliang Shen,Ji-Ting Hou,Zhipeng Li
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2022-08-02
卷期号:94 (32): 11159-11167
被引量:13
标识
DOI:10.1021/acs.analchem.2c01189
摘要
Pancreatic cancer (PC) is one of the most lethal cancers worldwide, which is usually diagnosed in the advanced stage and is highly resistant to traditional chemotherapy, radiotherapy, and immunotherapy. Therefore, there is an urgent need for developing new PC-specific imaging and treatment. In this study, an quinone oxidoreductase 1 (NQO-1)-activated near-infrared (NIR) agent, ICy-Q, was synthesized. ICy-Q is almost nonemissive, while its NIR emission at 705 nm is triggered by NQO-1-induced reduction in the PC cells. In addition, the reduction product, ICy-OH, is specifically enriched in mitochondria and lysosomes and acts as an effective chemotherapeutic agent to selectively induce pancreatic cancer cell death via the cell pyroptosis pathway. Further studies have shown that ICy-Q is suitable for ex vivo imaging of clinical PC sections and solid tumors from patients. We expect this study will be helpful in the future for the design of targeted theranostic agents for PC.
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