Nanoscale MOFs: From synthesis to drug delivery and theranostics applications

药物输送 纳米技术 金属有机骨架 光热治疗 靶向给药 材料科学 癌症治疗 正电子发射断层摄影术 医学 癌症 化学 吸附 有机化学 内科学 放射科
作者
Mengli Ding,Wenbo Liu,Ruxandra Gref
出处
期刊:Advanced Drug Delivery Reviews [Elsevier BV]
卷期号:190: 114496-114496 被引量:194
标识
DOI:10.1016/j.addr.2022.114496
摘要

Since the first report in 1989, Metal-Organic Frameworks (MOFs) self-assembled from metal ions or clusters, as well as organic linkers, have attracted extensive attention. Due to their flexible composition, large surface areas, modifiable surface properties, and their degradability, there has been an exponential increase in the study of MOFs materials, specifically in drug delivery system areas such as infection, diabetes, pulmonary disease, ocular disease, imaging, tumor therapy, and especially cancer theranostics. In this review, we discuss the trends in MOFs biosafety, from "green" synthesis to applications in drug delivery systems. Firstly, we present the different "green" synthesis approaches used to prepare MOFs materials. Secondly, we detail the methods for the functional coating, either through grafting targeting units, poly(ethylene glycol) (PEG) chains or by using cell membranes. Then, we discuss drug encapsulation strategies, host-guest interactions, as well as drug release mechanisms. Lastly, we report on the drug delivery applications of nanoscale MOFs. In particular, we discuss MOFs-based imaging techniques, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), positron emission tomography (PET), and fluorescence imaging. MOFs-based cancer therapy methods are also presented, such as photothermal therapy (PTT), photodynamic therapy (PDT), radiotherapy (RT), chemotherapy, and immunotherapy.
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