Advances in dual-sensing bioprobes for simultaneous monitoring ATP and various biological species

Adenosine triphosphate (ATP) serve as a crucial energy source within living organisms, intricately linked to essential physiological processes. Consequently, the development of bioprobes capable of spatiotemporally detecting ATP within living systems has become imperative. Recent focus has centered on creating bioprobes with high sensitivity and selectivity, enabling the simultaneous detection of ATP and biological species. These bioprobes demonstrate complementary interactions between ATP and various biological factors, such as reactive oxygen species, thiols, metals and enzymes, enabling the exploration of relevant physiological and pathological states. This review provides a comprehensive overview of recent research trends in the design of chemical probes tailored for the dual detection of ATP and other important biological components over the past five years. In particular, the review delves into their design strategies, detection mechanisms, optical properties, and extensively covers physiological and pathological models, including applications in bioimaging. Furthermore, the discussion encompasses forthcoming development strategies and research prospects.