The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives

肠道菌群 菌群(微生物学) 免疫系统 中医药 结直肠癌 癌症 乳腺癌 医学 机制(生物学) 生物 免疫学 癌症研究 内科学 病理 细菌 替代医学 哲学 遗传学 认识论
作者
Xuejiao Wei,Fei Wang,Peng Tan,Huiming Huang,Zhuguo Wang,Jinxin Xie,Longyan Wang,Dongxiao Liu,Zhongdong Hu
出处
期刊:Pharmacological Research [Elsevier]
卷期号:203: 107148-107148 被引量:3
标识
DOI:10.1016/j.phrs.2024.107148
摘要

The gut microbiota, known as the "forgotten organ" and "human second genome," comprises a complex microecosystem. It significantly influences the development of various tumors, including colorectal, liver, stomach, breast, and lung cancers, through both direct and indirect mechanisms. These mechanisms include the "gut-liver" axis, the "lung-intestine" axis, and interactions with the immune system. The intestinal flora exhibits dual roles in cancer, both promoting and suppressing its progression. Traditional Chinese medicine (TCM) can alter cancer progression by regulating the intestinal flora. It modifies the intestinal flora's composition and structure, along with the levels of endogenous metabolites, thus affecting the intestinal barrier, immune system, and overall body metabolism. These actions contribute to TCM's significant antitumor effects. Moreover, the gut microbiota metabolizes TCM components, enhancing their antitumor properties. Therefore, exploring the interaction between TCM and the intestinal flora offers a novel perspective in understanding TCM's antitumor mechanisms. This paper succinctly reviews the association between gut flora and the development of tumors, including colorectal, liver, gastric, breast, and lung cancers. It further examines current research on the interaction between TCM and intestinal flora, with a focus on its antitumor efficacy. It identifies limitations in existing studies and suggests recommendations, providing insights into antitumor drug research and exploring TCM's antitumor effectiveness. Additionally, this paper aims to guide future research on TCM and the gut microbiota in antitumor studies.
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