Sulfatobetaine Synthesis from Epoxides and Tertiary Amine‐Sulfur Trioxide Complexes

Abstract The sulfatobetaine formation from epoxides and tertiary amine‐sulfur trioxide complexes was studied. It was revealed that heterocyclic tertiary amine‐sulfur trioxide complexes being the most electrophilic and reactive complexes produce sulfatobetaines in 15.5–62.6 % isolation yields, the aliphatic tertiary amine sulfur‐trioxide complexes failed to form the expected products. The presence of the amine taken in 5‐fold excess improves the isolation yields of the sulfatobetaines (52–100 %).