乙酰胆碱酯酶
半日花
阿切
姜科
萜类
抑制性突触后电位
化学
立体化学
二萜
圆二色性
高良姜
酶
传统医学
生物化学
生物
根茎
医学
神经科学
作者
Bo Zhou,Mengjia Guo,Xinman Zhao,Xiaolong Li,Shaohuan Liu,Xiangchun Shen,Nenling Zhang
标识
DOI:10.1080/14786419.2024.2346269
摘要
A new labdane diterpene (1), two new norsesquiterpenoids (2-3), as well as eight known terpenoids (4-11) were isolated from the seeds of Alpinia galanga (Zingiberaceae). Their structures and absolute configurations were elucidated by 1D, 2D NMR, MS, and comparison of their experimental and calculated electronic circular dichroism (ECD). The acetylcholinesterase (AChE) inhibitory activities of all the isolated compounds (1-11) were evaluated and the result showed that compounds 6 and 9 had inhibitory activity against AChE, with IC50 values at 295.70 and 183.91 μM, whereas other compounds did not show any inhibitory activity.
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