细胞周期蛋白D1
癌症研究
胶质母细胞瘤
细胞凋亡
细胞周期
表观遗传学
U87型
细胞周期检查点
细胞培养
药品
细胞
细胞周期蛋白
癌症
化学
药理学
生物
医学
生物化学
内科学
基因
遗传学
作者
Morvarid Soleiman,Mehrnoosh Fathi‐Roudsari,Khosro Khajeh,Amir Maghsoudi
标识
DOI:10.1080/07357907.2024.2345183
摘要
Glioblastoma multiforme (GBM), is a frequent class of malignant brain tumors. Epigenetic therapy, especially with synergistic combinations is highly paid attention for aggressive solid tumors like GBM. Here, RSM optimization has been used to increase the efficient arrest of U87 and U251 cell lines due to synergistic effects. Cell lines were treated with SAHA, 5-Azacytidine, GSK-126, and PTC-209 individually and then RSM was used to find most effective combinations. Results showed that optimized combinations significantly reduce cell survival and induce cell cycle arrest and apoptosis in both cell lines. Expression of cyclin B1 and cyclin D1 were decreased while caspase3 increased expression.
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