Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

特奈特普酶 缺血性中风 医学 闭塞 冲程(发动机) 人口 纤溶剂 随机对照试验 心脏病学 内科学 溶栓 组织纤溶酶原激活剂 缺血 心肌梗塞 工程类 环境卫生 机械工程
作者
Shelagh B. Coutts,Sandeep Ankolekar,Ramana Appireddy,Juan F. Arenillas,Zarina Assis,Peter Bailey,Philip A. Barber,Rodrigo Bazán,Brian Buck,Kennedy R. Lees,Marie‐Christine Camden,Bruce Campbell,Leanne K. Casaubon,Luciana Catanese,Kausik Chatterjee,Philip Choi,Brian Clarke,Dar Dowlatshahi,Julia Ferrari,Olga Rukovets,Aravind Ganesh,Darshan Ghia,Mayank Goyal,Stefan Greisenegger,Omid Halse,MacKenzie Horn,Gary Hunter,Oje Imoukhuede,Peter J. Kelly,James Kennedy,Carol Kenney,Timothy Kleinig,Kailash Krishnan,Fabrício Oliveira Lima,Jennifer Mandzia,Martha Marko,Sheila Cristina Ouriques Martins,George Medvedev,Bijoy K. Menon,Sachin Mishra,Carlos A. Molina,Aimen Moussaddy,Keith W. Muir,Mark Parsons,Andrew M W Penn,Arthur Pille,Octávio Marques Pontes‐Neto,Christine Roffe,Joaquín Serena,Robert Simister,Nishita Singh,Neil J. Spratt,Daniel Strbian,Carol Huilian Tham,M Ivan Wiggam,David Williams,M Willmot,Teddy Y. Wu,Amy Yu,George Zachariah,Atif Zafar,Charlotte Zerna,Michael D. Hill,Marina Salluzzi,Nicole Blenkin,Ashley Dueck,Craig Doram,Qiao Zhang,Carol Kenney,Karla J. Ryckborst,Shelly Bohn,Quentin Collier,Frances C. Taylor,Brendan Cord Lethebe,Anitha Jambula,Kayla Sage,L. Gerard Toussaint,Supryia Save,Jaclyn Lee,Nihay Laham-Karam,Asfia Sultan,Deepak Agrawal,Amith Sitaram,Andrew M. Demchuk,Andrew Lockey,A. Micielli,Ankur Wadhwa,Babawale Arabambi,B.B. Graham,Chrysi Bogiatzi,Darshan Doshi,Debabrata Chakraborty,Diana Kim,Denise Vasquez,Deepwant Singh,Dominic Tse,Earl C. Harrison,Eric E. Smith,Erika Teleg,Evgenia Klourfeld,Gary Klein,Ivy Sebastian,John Grimley Evans,Janka Hegedus,Julie Kromm,Katie Lin,Katrina Hannah D. Ignacio,Kimia Ghavami,Mohd Pazudin Ismail,Margaret Moores,Marie-Andrée Panzini,Matthew Boyko,Mohammed Almekhlafi,Nancy Newcommon,Nicholas Maraj,Oje Imoukhuede,Ondřej Volný,Peter K. Stys,Phillippe Couillard,Piyush Ojha,Prasanna Venkatesan Eswaradass,Raed A. Joundi,Ravinder Singh,R.M. Asuncion,Ryan T. Muir,Sadanand Dey,Salman Mansoor,Sanchea Wasyliw,Sanjai Nagendra,Sherry Hu,Shorog Althubait,Shuo Chen,Simerpreet Bal,Stephen van Gaal,Steven Peters,Sucharita Ray,S. K. Chaturvedi,Sandhya Subramaniam,Vivian Fu,Karina Villaluna,G. L. Maclean,Princess King-Azote,Chaoyang Ma,Alyson Plecash,Colleen Murphy,J M Gorman,Laura Wilson,Qianzhou Lv,Oscar Benevente,P. Teal,Samuel Yip,Shivtaj Mann,Belinda Dewar,M. Demetroff,Reham Shamloul,R. Beardshaw,Susan B. Roberts,D. Blaquiere,Grant Stotts,Michel Shamy,Olena Bereznyakova,Robert Fahed,Walid Alesefir,Suzy Lavoie,Annette Haché,Karine Collard,Ariane Mackey,Stéphanie Gosselin-Lefebvre,Steve Verreault,Brittany Beauchamp,Lindsay Lambourn,Alexander V. Khaw,Li Mai,Luciano A. Sposato,María Bres Bullrich,R. Azarpazhooh,Sebastián Fridman,Arunima Kapoor,Angela Southwell,Edoardo Bardi,Idris Fatakdawala,Maneesha Kamra,Karen Lucasechi Lopes,Najla Popel,Vadood Norouzi,A. Liu,Ann-Marie Liddy,B. Ghoari,Christine Hawkes,C.A. Enriquez,David J. Gladstone,Alejandro Manosalva,Houman Khosravani,Julia Hopyan,Kousik Sivakumar,Minnette T. Son,Mark I. Boulos,M.A. Hamind,Richard H. Swartz,Robert Murphy,Stephanie Reiter,Tony Fitzpatrick,V. Bhandari,J Good,Melanie Penn,Mary D. Naylor,Steven A. Frost,Arthur Cayley,Farhana Akthar,J. Williams,Libby Kalman,Lisa Crellin,Rebecca Wiegner,Ram Singh,Thomas G. Stewart,W. W. K. To,Sarman Singh,Aleksandra Pikula,Cheryl Jaigobin,Federico Carpani,Frank L. Silver,Helena Janssen,Joanna D. Schaafsma,Martín del Campo,Mohammed A. Alskaini,Phavalan Rajendram,Paige Fairall,Bonny Granfield,Dorothy H. Crawford,Juline Jabs,Laura White,Leka Sivakumar,Lori Piquette,Thanh N. Nguyen,Ali Zohair Nomani,Aaron Wagner,Anas Alrohimi,Anjum Rashid Butt,Alicia D’Souza,Bikram Prasad Gajurel,Chetan Vekhande,Hemant Kamble,Hayrapet Kalashyan,María Jesús Lloret,Mowad Benguzzi,Nazeem Arsalan,N. Ishaque,R. Ashayeriahmadabad,R. Samiento,Saeed Hosseini,Stephanie Kazi,Saurav Das,T. Sugumar,Neil J. Spratt,Pawel Kostyrko,Alexandra Muccilli,A.G. Saposnik,C. Vandervelde,Kanchana Ratnayake,S. McMillan,Aristeidis H. Katsanos,Ashkan Shoamanesh,Demetrios J. Sahlas,Vaman Naidoo,Vladimir Todorov,H Toma,Jaskiran Brar,Jungwha Lee,Mike Horton,Shuo Chen,Elaine Shand,Stuart Weatherby,A Jin,Bryce A. Durafourt,Shirin Jalini,Aaron Gardner,Charlotte Tyson,Emily Junk,Kimberley Foster,K. Bolt,Nicole J. Sylvain,S.W. Maley,Lilian Urroz,Lissa Peeling,Michael Kelly,Timothy Kleinig,Robert N. Cooley,Jeanne Teitelbaum,Alaae Boutayeb,Angela Moore,Edward Cole,Lloyd Waxman,N. Ben-Amor,R. Sanchez,Samah R. Khalil,Ahmad Nehme,Claudine Legault,Donatella Tampieri,Eric Ehrensperger,Lis Proença Vieira,M. Cortes,Mark Angle,Mathew Hannouche,Mohamed Badawy,Klaus Werner,Sonja Wieszmuellner,A. Langer,A. Gisold,Heidemarie Zach,Paulus Rommer,Susanne Macher,Stephan Blechinger,Wolfgang Marik,Wolfgang Series,M. Baumgartinger,Stefan Krebs,Juhani Koski,S. Eirola,T. Ivanoff,A. Erakanto,L. Kupari,Gerli Sibolt,Jorma Panula,Liisa Tomppo,Marjaana Tiainen,Matti Ahlström,Nicolas Martinez Majander,O Suomalainen,Silja Räty,Christopher Levi,E. Kerr,Jason W. Allen,Lara Kaauwai,L. Belevski,Matthew Russell,Sally Ormond,Andrew Chew,Andre Loiselle,Angela T Royan,Brett Hughes,Carlos García Esperón,Elizabeth Pepper,Ferdinand Miteff,Jiang He,Mitchell Lycett,Michelle S. Min,Nigel P Murray,Nils Pavey,R. Starling de Barros,Sidhu P. Gangadharan,S. Dunkerton,Stephen G. Waller,Tamara Canento Sánchez,Tom Wellings,Grant W. Edmonds,Karen Whittaker,Michael T. Ewing,Patricia Lee,Rowena Singkang,Amy McDonald,Alvani D. Santos,Changyong Shin,David M. Jackson,Jessica Tsoleridis,L. Fisicchia,M. Passeri,Neeta Shenoy,Albert Hofman,Angelos Sharobeam,Anna Balabanski,A. Park,Cameron Williams,D. Pavlin-Premri,Edrich Rodrigues,Fana Alemseged,Felix Ng,Hang Zhao,James Beharry,Jo Lyn Ng,James D Williamson,John W.P. Wong,K. Li,Michael Kwan,Michael Valente,Nawaf Yassi,Robert N. Cooley,Vignan Yogendrakumar,Brian McNamara,Claire Buchanan,Christine McCarthy,George Thomas,Krista Stephens,Min Young Chung,M C Chung,Michelle J. Tang,Tomislav Busch,Tanya Frost,Richard K. Lee,N J Stuart,Naila Pachani,Ashvini Menon,Branko Borojevic,C. M. Linton,Guillermo García,Elizabeth Callaly,HM Dewey,Jing Liu,Jingwen Chen,John Norrie,Konrad Nowak,Karen Jung,Nathaniel Lizak,Oneil G. Bhalala,P. Park,Patricia Grace Chua Tan,Rui Martins,Robert Cody,Raeburn B Forbes,S.K. Chen,Sze‐Yuan Ooi,Shengxian Tu,Y.L. Dang,Zhiyu Ling,Jennifer Cranefield,Roy Drew,Aaron C. Tan,Craig Kurunawai,Jackson Harvey,Jeyaledchumy Mahadevan,Lavenia Cagi,Logesh Palanikumar,Linda Chia,Robby Miguel Goh,Shaddy El-Masri,Berzenn Urbi,Catherine Rapier,Haylee Berrill,H C McEvoy,R. W. Dunning,Santhosh Kuriakose,Thomas Chad,V. Sapaen,Arman Sabet,Darshan Shah,David Gan Eng Yeow,Kathryn S. Lilley,Kathleen Ward,Marai Mozhy Mahizhnan,M. Tan,Christopher J. Lynch,Sam Coveney,Kenneth J. Tobin,John McCabe,Michael Marnane,Shelley L. Murphy,Margaret Large,Barry Moynihan,K. Boyle,Estela Sanjuán,Mireia Sanchis,Sandra Boned,Olalla Pancorbo,V. Sala,Luis I. García,Álvaro García‐Tornel,Jesús Juega,Jorge Pagola,Katherine E Santana,Manuel Requena,Marián Muchada,Montse Olivé,Pardo Lozano,Marta Rubiera,Matías Deck,Noelia Rodríguez,B.A. Lavin Gomez,F.J. Reyes Muñoz,Ángela Sánchez‐Algaba Gómez,Ai Calleja Sanz,E Cortijo Garcia,G. Valle Peñacoba,María Elena Ramos,Mercedes de Lera Alfonso,Anna Feliu,Laura Pardo,Paula Ramírez,Abel Murillo,David Dominguez,Jorge Rodríguez,Mikel Terceño Izaga,María Dolores Reina,Saima Bashir,Ursula Bojaryn,Victor Augusto Vera Monge,Yolanda Silva,R. R Siew,Sherwin J. U. Agustin,Christopher Seet,Tianming Teng,A. d'Emden,Andrew J. Murray,Angela Welch,Kim Hatherley,Nicola C. Day,Wendy Smith,Ellen Macrae,Erin Mitchell,Ammad Mahmood,Jennifer Elliot,S. Neilson,Viveka Biswas,Claire Brown,Adam Lewis,A Ashton,David J. Werring,Richard Perry,Raafia Muhammad,Y.C. Lee,A E Black,A. Robinson,Andrew Williams,Azra Banaras,C. Cahoy,G. Raingold,Mark Marinescu,N. Atang,Nathalie Bason,Nadia Francia,S Obarey,Shez Feerick,Jeffery Joseph,U Schulz,Robert Irons,John T. Benjamin,Linda Quinn,M. Jhoots,Rachel Teal,Gary A Ford,George Harston,H. Bains,Ivie Gbinigie,Philip Mathieson,Robert Irons,Cheul-Muu Sim,Elizabeth Hayter,Kathleen A. Kennedy,Lauren Binnie,Naomi Priestley,R. Williams,Rita Ghatala,Samuel J. Stratton,Andrew R. Blight,Li Zhang,Andrew Davies,Helen Duffy,Jason D. Roberts,Jack Homer,Karen Roberts,K. Dodd,Kathryn Cawley,Carmen Martín,S Leason,S. Cotgreave,Tracey Taylor,Arumugam Nallasivan,Shozeb Haider,Tia Chakraborty,Thomas J. Webster,Álvaro Lambea‐Gil,Bryan Martin,Bernadette Joseph,C. Cabrera,David Rodrigo,John Man,Jacobo Córdova Aquino,S. Sebastian,Maria Österdahl,Michael Kwan,M. Sunil Mathew,Noriyuki Ike,P Bello,Elisabeth Verpoorte,Rodrigo Fuentes,Ruchir Shah,Sheila Mashate,Tarak Patel,U. Nwanguma,Vivek Pravin Dave,A. Haber,A. Lee,Anthony O’Sullivan,Brendan Drumm,Angela Dawson,T. Matar,Viveka Biswas,Dionne Roberts,Eugene Taylor,Elisabeth Rounis,Abdel-Ghanny M El-Masry,Caitlin O'Hare,Dheeraj Kalladka,Sohaa Jamil,Jacques Auger,Oishik Raha,Michael D. Evans,Frederick W. Vonberg,Sadaf Kalam,Asim A. Sheikh,I H Jenkins,Jacob George,Joseph Kwan,Jelena Blagojević,J. Chauveau,Michael Haji-Coll,Masaki Tsuda,Marawan A. Elbaset,N. Winterkron,N. Thanbirajah,Orsolya Vittay,R. Karim,Ruaridh Cameron Smail,Sumaiyyah Gauhar,S. Elmamoun,SK Malani,Shyam Kelavkar,Joanne Hiden,Peter Ferdinand,Ranjan Sanyal,R Varquez,Bryn M. Smith,Cassandra A. Okechukwu,Edward Fox,Emma Collins,Kathleen Courtney,Sudhir Tauro,Cynthia Patterson,Dennis J. McShane,E. Kerr,Grant S. Roberts,J. McIImoyle,K. McGuire,Patricia Fearon,Brendan Steinfort,K. Isaacs,Kristi Lucas,Larissa L. Smith,L. Dews,Michelle Bates,Stephanie Lawrence,S. Heeley,Vivek P. Patel,Y Chin,D. Sims,Edward Littleton,Jattinder Khaira,KarthickT Nadar,Agnieszka Kieliszkowska,B. Sari,Carmona Belo,Eric E. Smith,E.Y. Manolo,John Aeron‐Thomas,Martina Doheny,Miguel García-Pardo,Mónica Recamán,M.C. Tibajia,Mohamed Aissa,Yee‐Haur Mah,Tao Yu,Vivek P. Patel,Salvadeeswaran Meenakshi-Sundaram,Simon Heller,Rana Alnasser Alsukhni,O. Williams,Mohamed Farag,Matthew Benger,Anish Engineer,Mohamed Aissa,S. Bayhonan,Sean Conway,Ajay Bhalla,D. Nouvakis,Evangelia Theochari,F. Boyle,James Teo,Josh King‐Robson,K.Y. Law,L. Sztriha,Mohd Pazudin Ismail,Andrew McGovern,Donald C. Day,J. Mitchell-Douglas,Joseph Francis,Arshad Muhammad Iqbal,P. Punjabivaryani,Javier Reyes,Maria-Soledad Reyes,Mehrnoosh Pauls,Ashesh N. Buch,Aleksandra Hedström,Cary T. Hutchinson,C. Kirkland,James Newham,Gail M. Wilkes,Lora E. Fleming,N.A. Fleck,André Luiz Pellacani França,Bruna Cristine Chwal,Carolina Oldoni,Gabriel Paulo Mantovani,G Noll,Luca Zanella,Maurizio R. Soma,Thaís Leite Secchi,Wyllians Vendramini Borelli,Brunna P. Rimoli,G. Silva,L.A. Machado Galvao Mondin,Riccardo Cerantola,Alexandre Kracker Imthon,Atsushi Esaki,Millene Rodrigues Camilo,Otavio Costa Vincenzi,Raulle Sol Cruz,Matheus Bernardon Morillos,Guilherme Gualberto Rodrigues,Kathleen Ferreira,Andréia Martini Pazini,M.A. Pena Pereira,A.L.A. de Albuquerque,C.E. Massote Fontanini,C.F. Matinez Rubio,Davi Teixeira dos Santos,Flávia Aparecida Dias,F.F.A. Alves,C. Milani,Bianca L. Santos,Fernanda Cristina Winckler,Jorge Teodoro de Souza,L.A.M. Bonome,V.A. Cury Silva,Robson Sarmento Teodoro,Gabriel Pinheiro Módolo,Natália Cristina Ferreira,Daniel Fabiano Barbosa dos Santos,J.C. dos Santos Moreira,Alessandra Braga Cruz Guedes de Morais,J. Vieira,L. Pierot,J.P. de Queiroz
出处
期刊:The Lancet [Elsevier]
卷期号:403 (10444): 2597-2605 被引量:6
标识
DOI:10.1016/s0140-6736(24)00921-8
摘要

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Cat应助玉暖阳采纳,获得10
刚刚
犹豫含羞草完成签到,获得积分10
刚刚
青戈完成签到,获得积分10
刚刚
小小de小小完成签到,获得积分10
刚刚
mm完成签到,获得积分20
1秒前
zhangzhang完成签到,获得积分10
1秒前
linfordlu完成签到,获得积分0
1秒前
安安完成签到,获得积分20
1秒前
今后应助孙佳琦采纳,获得10
1秒前
CodeCraft应助顾化蛹采纳,获得10
2秒前
3秒前
甜甜清发布了新的文献求助10
4秒前
Akim应助嘎嘎嘎采纳,获得10
4秒前
完美世界应助小乔同学采纳,获得10
4秒前
瑶瑶要加油完成签到,获得积分10
4秒前
5秒前
哭泣慕晴完成签到 ,获得积分10
5秒前
Tapioca完成签到,获得积分10
5秒前
feng完成签到,获得积分10
6秒前
隐形曼青应助顶刊我来了采纳,获得10
6秒前
stars发布了新的文献求助10
6秒前
6秒前
8秒前
Kiki发布了新的文献求助10
8秒前
123456完成签到,获得积分10
9秒前
记忆关注了科研通微信公众号
9秒前
huohua完成签到,获得积分10
9秒前
10秒前
10秒前
黄龙光完成签到 ,获得积分10
10秒前
细菌学家完成签到 ,获得积分10
10秒前
完美世界应助yey采纳,获得10
10秒前
77z完成签到,获得积分10
11秒前
superming发布了新的文献求助10
12秒前
13秒前
zhangzhang发布了新的文献求助10
13秒前
abc123发布了新的文献求助30
13秒前
黄龙光关注了科研通微信公众号
14秒前
彭于晏应助bb采纳,获得10
14秒前
新明发布了新的文献求助10
14秒前
高分求助中
Handbook of Fuel Cells, 6 Volume Set 1666
Floxuridine; Third Edition 1000
Tracking and Data Fusion: A Handbook of Algorithms 1000
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 800
消化器内視鏡関連の偶発症に関する第7回全国調査報告2019〜2021年までの3年間 500
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 500
Framing China: Media Images and Political Debates in Britain, the USA and Switzerland, 1900-1950 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 冶金 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 2861490
求助须知:如何正确求助?哪些是违规求助? 2466871
关于积分的说明 6688461
捐赠科研通 2158099
什么是DOI,文献DOI怎么找? 1146415
版权声明 585109
科研通“疑难数据库(出版商)”最低求助积分说明 563292