自愈水凝胶
粘弹性
PEG比率
材料科学
应力松弛
生物物理学
组织工程
纳米技术
粘附
钙
化学
生物医学工程
高分子化学
复合材料
财务
经济
生物
医学
蠕动
冶金
作者
Hongqiang Yu,Ziqian Yan,Cécile A. Dreiss,Gustavo González‐Gaitano,James A. Jarvis,Eileen Gentleman,Ricardo M. P. da Silva,Agamemnon E. Grigoriadis
标识
DOI:10.1002/adhm.202400472
摘要
Synthetic hydrogels provide controllable 3D environments, which can be used to study fundamental biological phenomena. The growing body of evidence that cell behavior depends upon hydrogel stress relaxation creates a high demand for hydrogels with tissue-like viscoelastic properties. Here, a unique platform of synthetic polyethylene glycol (PEG) hydrogels in which star-shaped PEG molecules are conjugated with alendronate and/or RGD peptides, attaining modifiable degradability as well as flexible cell adhesion, is created. Novel reversible ionic interactions between alendronate and calcium phosphate nanoparticles, leading to versatile viscoelastic properties with varying initial elastic modulus and stress relaxation time, are identified. This new crosslinking mechanism provides shear-thinning properties resulting in differential cellular responses between cancer cells and stem cells. The novel hydrogel system is an improved design to the other ionic crosslink platforms and opens new avenues for the development of pathologically relevant cancer models, as well as minimally invasive approaches for cell delivery for potential regenerative therapies.
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