细胞内
膜
催化作用
化学
抗生素耐药性
抗生素
基因
微生物学
生物化学
生物
作者
Xuan Hou,Yunxin Zhang,Jiajun Lu,Qian Li,Ling Li,Baoyu Gao,Yan Wang
出处
期刊:Desalination
[Elsevier]
日期:2024-08-01
卷期号:583: 117711-117711
被引量:1
标识
DOI:10.1016/j.desal.2024.117711
摘要
The removal of antibiotic resistance genes (ARGs) is crucial to prevent the proliferation of antibiotic resistance. In this study, we successfully removed intracellular ARGs using the PMS/Co@CM system, which involved activating peroxymonosulfate (PMS) with a catalytic membrane composed of Co3O4 and carbon nanotubes. In the PMS/Co@CM system, 1O2 was the primary reactive oxygen species (ROS) responsible for intracellular ARGs removal. However, the presence of sulfamethoxazole (SMX) in the water samples significantly reduced the efficiency of removing intracellular ARGs in the PMS/Co@CM system although SMX was degraded by •SO4−. This can be attributed to the selective pressure of SMX, which elevated intracellular Superoxide Dismutase (SOD) levels while decreasing Propidium Iodide (PI) levels in cells. Consequently, this led to heightened antioxidant defense and reduced membrane permeability, thereby enhancing cell resistance to 1O2 generated by the PMS/Co@CM system. Encouragingly, a typical UV disinfection process facilitated the removal of residual intracellular ARGs in the effluent of the PMS/Co@CM system, attributed to decreased SOD levels and increased intracellular 1O2 by UV irradiation. These findings contribute to the theoretical understanding of effective ARGs removal and aid in the development of more efficient removal technologies.
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