脂质体
槲皮素
疾病
药理学
薄荷醇
脑功能
医学
神经科学
阿尔茨海默病
化学
生物
内科学
生物化学
抗氧化剂
有机化学
作者
Wanying Liu,Yang Yu,Jiachen Zang,Yang Liu,Feng-rui Li,Lu Zhang,Rui-bo Guo,Liang Kong,Ling-yue Ma,Xuetao Li
标识
DOI:10.1021/acschemneuro.4c00109
摘要
Oxidative stress and neuroinflammation in the aging brain are correlated with the development of neurodegenerative diseases, such as Alzheimer's disease (AD). The blood–brain barrier (BBB) poses a significant challenge to the effective delivery of therapeutics for AD. Prior research has demonstrated that menthol (Men) can augment the permeability of the BBB. Consequently, in the current study, we modified Men on the surface of liposomes to construct menthol-modified quercetin liposomes (Men-Qu-Lips), designed to cross the BBB and enhance quercetin (Qu) concentration in the brain for improved therapeutic efficacy. The experimental findings indicate that Men-Qu-Lips exhibited good encapsulation efficiency and stability, successfully crossed the BBB, improved oxidative stress and neuroinflammation in the brains of aged mice, protected neurons, and enhanced their learning and memory abilities.
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