Electrospun Nanofiber Scaffold for Skin Tissue Engineering: A Review

纳米纤维 组织工程 脚手架 再生(生物学) 静电纺丝 材料科学 纳米技术 自愈水凝胶 生物医学工程 工程类 复合材料 聚合物 生物 细胞生物学 高分子化学
作者
Jingwen Wu,Fenglin Yu,Mingfei Shao,T. Zhang,Weipeng Lu,Xin Chen,Yihu Wang,Yanchuan Guo
出处
期刊:ACS applied bio materials [American Chemical Society]
卷期号:7 (6): 3556-3567 被引量:2
标识
DOI:10.1021/acsabm.4c00318
摘要

Skin tissue engineering (STE) is widely regarded as an effective approach for skin regeneration. Several synthetic biomaterials utilized for STE have demonstrated favorable fibrillar characteristics, facilitating the regeneration of skin tissue at the site of injury, yet they have exhibited a lack of in situ degradation. Various types of skin regenerative materials, such as hydrogels, nanofiber scaffolds, and 3D-printing composite scaffolds, have recently emerged for use in STE. Electrospun nanofiber scaffolds possess distinct advantages, such as their wide availability, similarity to natural structures, and notable tissue regenerative capabilities, which have garnered the attention of researchers. Hence, electrospun nanofiber scaffolds may serve as innovative biological materials possessing the necessary characteristics and potential for use in tissue engineering. Recent research has demonstrated the potential of electrospun nanofiber scaffolds to facilitate regeneration of skin tissues. Nevertheless, there is a need to enhance the rapid degradation and limited mechanical properties of electrospun nanofiber scaffolds in order to strengthen their effectiveness in soft tissue engineering applications in clinical settings. This Review centers on advanced research into electrospun nanofiber scaffolds, encompassing preparation methods, materials, fundamental research, and preclinical applications in the field of science, technology, and engineering. The existing challenges and prospects of electrospun nanofiber scaffolds in STE are also addressed.
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