Radiological Features of Bone Lymphoma on CT and MRI. A Retrospective Monocentric Series of 56 Patients

Bone lymphoma is a rare bone neoplasm consisting of malignant lymphoid cells. It is classified as primary bone lymphoma (PBL) or secondary bone lymphoma (SBL). PBL is a neoplasm producing one or more tumor masses within the bone, with no extra-regional lymph-node involvement or other extranodal lesions ( 1 Cleven AHG Ferry JA. Primary non-Hodgkin lymphoma of bone. The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours - Soft Tissue and Bone Tumors. 5th ed. IARC Press, Lyon2020: 489-491 Google Scholar ). It accounts for approximately 7% of all malignant bone tumors ( 1 Cleven AHG Ferry JA. Primary non-Hodgkin lymphoma of bone. The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours - Soft Tissue and Bone Tumors. 5th ed. IARC Press, Lyon2020: 489-491 Google Scholar , 2 Bhagavathi S Micale MA Les K Primary bone diffuse large B-cell lymphoma: clinicopathologic study of 21 cases and review of literature. Am J Surg Pathol. 2009; 33: 1463-1469 Crossref PubMed Scopus (39) Google Scholar ). SBL is a bone lymphoma with systemic disease ( 1 Cleven AHG Ferry JA. Primary non-Hodgkin lymphoma of bone. The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours - Soft Tissue and Bone Tumors. 5th ed. IARC Press, Lyon2020: 489-491 Google Scholar ). The diagnosis of bone lymphoma requires histopathologic analysis of a tumoral tissue sample. However, there is risk of a negative biopsy, especially with bone tissue biopsy, because bone lymphomas consist of loose tissue with areas of necrosis, prone to crush artifacts and fragmentation during preparation, which may interfere with immunohistochemical analysis ( 3 Kitsoulis P Vlychou M Papoudou-Bai A et al. Primary lymphomas of bone. Anticancer Res. 2006; 26: 325-337 PubMed Google Scholar ).