A Miniaturized Prototype for Continuous Noninvasive Transcutaneous Oxygen Monitoring

Luminescent oxygen sensing is employed for measuring the partial pressure of oxygen diffusing through the skin, named transcutaneous oxygen. Two well-known approaches are intensity- and lifetime-based measurements for assessing transcutaneous oxygen. The lifetime-based technique is preferable as it offers lower susceptibility to optical path changes and reflections compared to the intensity-based method. High-resolution lifetime capturing is critical to accurate transcutaneous oxygen measurements from the human body. This study proposes a miniaturized prototype based on a multimodal analog front end, ADPD4101, and custom firmware. We have demonstrated that the prototype could detect small changes in the lifetime with high resolution, showing its suitability for future human subject tests. We implemented the prototype on a 68 mm × 43 mm printed circuit board (PCB) and consumes the power ×of 39 mW.