医学
特应性皮炎
重症监护医学
疾病
杜皮鲁玛
全身疗法
奥马佐单抗
疾病管理
临床试验
皮肤病科
免疫学
内科学
免疫球蛋白E
癌症
乳腺癌
抗体
帕金森病
作者
Lawrence F. Eichenfield,Mark Boguniewicz,Christine T. Lauren,Donald Y.M. Leung,Moise L. Levy,Lynda C. Schneider,Elaine C. Siegfried,Wynnis L. Tom,Amy S. Paller
出处
期刊:Dermatology
[S. Karger AG]
日期:2024-10-15
卷期号:: 1-26
摘要
Atopic dermatitis (AD) is a chronic, type-2 mediated, inflammatory skin disease characterized by intense pruritus, disruption of skin barrier function, and immune dysregulation. Management strategies for AD are routinely determined based on disease severity. First-line treatment begins with basic skin care and topical anti-inflammatory medication, which is typically sufficient for the management of mild-to-moderate disease. For those patients with moderate-to-severe disease, systemic therapy is often required. This can involve off-label treatment with conventional immunosuppressant medications. However, this approach is limited by a lack of robust clinical trial data and safety concerns that necessitate close monitoring. The emergence of novel targeted biologics and small molecules to treat AD presents an opportunity to optimize AD management and patient outcomes by offering greater efficacy than traditional immunosuppressants and a favorable safety profile. As the treatment landscape shifts, clinicians can benefit from a standardized process of patient assessment and treatment, along with resources to help maintain contemporary knowledge of available therapeutic options. This United States (US)-based, expert-led consensus used a modified Delphi process to develop core recommendations for the use of systemic medications for the management of pediatric patients <18 years of age with moderate-to-severe AD.
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