卵泡液
多囊卵巢
生物
卵母细胞
内分泌学
内科学
载脂蛋白A1
蛋白质组
蛋白质组学
卵泡期
载脂蛋白B
胰岛素抵抗
细胞生物学
生物信息学
生物化学
医学
胰岛素
基因
胚胎
胆固醇
作者
Janusz Przewocki,Adam Łukaszuk,Grzegorz Jakiel,Izabela Wocławek-Potocka,Karolina Kłosińska,Jolanta Olszewska,Krzysztof Łukaszuk
标识
DOI:10.3390/ijms252111749
摘要
This study explores the proteomic composition of follicular fluid (FF) from women undergoing oocyte retrieval for in vitro fertilisation (IVF), with a focus on the effects of polycystic ovary syndrome (PCOS). FF samples were collected from 74 patients, including 34 with PCOS and 40 oocyte donors. Proteomic profiling using machine learning identified significant differences in protein abundance between the PCOS and control groups. Of the 484 quantified proteins, 20 showed significantly altered levels in the PCOS group. Functional annotation and pathway enrichment analysis pointed to the involvement of protease inhibitors and immune-related proteins in the pathophysiology of PCOS, suggesting that inflammation and immune dysregulation may play a key role. Additionally, HDL assembly was identified as a significant pathway, with apolipoprotein-AI (APOA1) and alpha-2-macroglobulin (A2M) as the major proteins involved. Notably, myosin light polypeptide 6 was the most downregulated protein, showing the highest absolute fold change, and may serve as a novel independent biomarker for PCOS.
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