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Recent Advances in Cyclodextrin‐Based Nanoscale Drug Delivery Systems

药物输送 纳米技术 环糊精 药品 生物利用度 纳米材料 材料科学 超分子化学 生物相容性 胶束 组合化学 化学 分子 有机化学 药理学 水溶液 医学
作者
Fuat Topuz,Tamer Uyar
出处
期刊:Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology [Wiley]
卷期号:16 (6)
标识
DOI:10.1002/wnan.1995
摘要

ABSTRACT Cyclodextrins (CDs) belong to a class of cyclic oligosaccharides characterized by their toroidal shape consisting of glucose units linked via α‐1,4‐glycosidic bonds. This distinctive toroidal shape exhibits a dual nature, comprising a hydrophobic interior and a hydrophilic exterior, making CDs highly versatile in various pharmaceutical products. They serve multiple roles: they act as solubilizers, stabilizers, controlled release promoters, enhancers of drug bioavailability, and effective means of masking undesirable tastes and odors. Taking advantage of these inherent benefits, CDs have been integrated into numerous nanoscale drug delivery systems. The resulting nanomaterials exploit the exceptional properties of CDs, including their ability to solubilize hydrophobic drugs for substantial drug loading, engage in supramolecular complexation for engineered nanomaterials, increase bioavailability for improved therapeutic efficacy, stabilize labile drugs, and exhibit biocompatibility and versatility. This paper compiles recent studies on CD functional nanoscale drug delivery platforms. First, we described the physicochemical and toxicological aspects of CDs, CD/drug inclusion complexation, and their impact on improving drug bioavailability. We then summarized applications for CD‐functional nano delivery systems based on polymeric, hybrid, lipid‐based nanoparticles, and CD‐based nanofibers. Particular interest was in the targeted applications and the function of the CD molecules used. In most applications, CD molecules were used for drug solubilization and loading, while in some studies, CD molecules were employed for supramolecular complexation to construct nanoscale drug delivery systems. Finally, the review concludes with a thoughtful consideration of the current challenges and outlook.
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