已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Corneal Opacity in the United States: An American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) Study

医学 验光服务 IRIS(生物传感器) 眼科 角膜混浊 角膜 人工智能 生物识别 计算机科学
作者
Rohan Bir Singh,Thomas H. Dohlman,Alexander R. Ivanov,Nathan Hall,Connor Ross,Tobias Elze,Joan W. Miller,Anja Lorch,Erdem Yüksel,Jia Yin,Reza Dana,Aaron Lee,Cecilia S. Lee,Leslie Hyman,Julia A. Haller,Suzann Pershing,Christina Thomas‐Virnig,Alex Miranda,Divya Srikumaran,Fasika A. Woreta,Flora Lum,Joan W. Miller,Anja Lorch
出处
期刊:Ophthalmology [Elsevier]
标识
DOI:10.1016/j.ophtha.2024.07.005
摘要

Purpose Vision loss associated with opacification of the cornea is one of the leading causes of blindness globally. However, the epidemiological data pertaining to the demographics, associated etiological causes and reduced vision in corneal opacity patients continue to be sparse. This study assesses the case frequencies, underlying etiologies, and vision outcomes in patients diagnosed with corneal opacity, in the United States. Design Retrospective cohort study Participants Patients in the IRIS® Registry (Intelligent Research in Sight) who were diagnosed with corneal opacity between January 1st, 2013, and November 30th, 2020. Methods The IRIS Registry contains demographic and clinical data of 79,887,324 patients who presented to eye clinics during the study period. We identified patients with corneal opacity using International Classification of Disease (ICD) codes (ICD-9, and -10) of "371" (corneal scar) and "H17" (corneal opacity), respectively. The analyzed data included demographic parameters included age, sex, race, ethnicity, and geographical location. We evaluated clinical data including laterality, etiology, disease descriptors, and best-corrected visual acuity (VA) up to 1 year before the onset (± 30 days), at the time of diagnosis, and at one year following diagnosis (± 30 days). Main outcome measures Case frequencies, etiology, and vision outcomes in patients diagnosed with corneal opacity. Results We identified 5,220,382 patients who were diagnosed with corneal opacity and scars using H17 (ICD-10) and 371.0 (ICD-9) codes over seven years. The case frequency of corneal opacity during the study period was 6,535 cases per 100,000 patients (6.5%). The mean age of the patients was 63.36±18.14 years and the majority were female (57.6%). In the cohort, 38.39% and 30.00% of patients had bilateral and unilateral corneal opacity, respectively. Most of the patients were White (69.13%), followed by Black or African American (6.84%), Asian (2.45%), American Indian or Alaska Native(0.34%), Native Hawaii or other Pacific Islander(0.19%). Among the patients with corneal opacity, 7.34% had Hispanic or Latino ethnicity. The primary etiologies associated with corneal opacity included corneal dystrophies (64.66%) followed by edema (18.25%), ulcer (7.78%), keratoconjunctivitis (7.18%), degeneration (5.62%), neovascularization (6.27%), and trauma (5.28%). Visual acuity of the patients significantly worsened due to corneal opacity (0.46±0.74 logMAR; ∼20/58 in Snellen) and did not improve to the baseline (0.37±0.68 logMAR, ∼20/46 in Snellen) post-management (0.43±0.77 logMAR, ∼20/54 in Snellen). The multiple linear regression analysis showed worse vision outcomes in females (compared to males), and Asian, Black or African American, and American Indian or Alaska Native (compared to White) patients. Additionally, worse vision outcomes were observed in patients with opacity associated with corneal malformation, degenerative disorders, edema, injury, and ulcer compared to those with hereditary corneal dystrophy. Conclusions Our study shows that the corneal opacity was diagnosed in 6.5% of the patients in the IRIS Registry and it was primarily associated with corneal dystrophies. The final vision outcomes in corneal opacity patients were significantly worse compared to baseline. The worse vision outcomes were associated with sociodemographic differences that might be associated with disparities in access, utilization, and care patterns.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Qian完成签到,获得积分10
1秒前
小团子发布了新的文献求助10
2秒前
清秀惜霜发布了新的文献求助10
3秒前
樱桃猴子应助bukeshuo采纳,获得10
3秒前
赘婿应助小团子采纳,获得10
14秒前
阳光森林完成签到 ,获得积分10
16秒前
烟花应助bukeshuo采纳,获得30
19秒前
22秒前
tjpuzhang完成签到 ,获得积分10
28秒前
wang发布了新的文献求助10
29秒前
万能图书馆应助bukeshuo采纳,获得10
33秒前
人小鸭儿大完成签到 ,获得积分10
34秒前
36秒前
科研通AI2S应助科研通管家采纳,获得10
37秒前
共享精神应助科研通管家采纳,获得30
37秒前
赘婿应助科研通管家采纳,获得10
37秒前
脑洞疼应助科研通管家采纳,获得10
37秒前
浅尝离白应助科研通管家采纳,获得10
38秒前
38秒前
Allen完成签到,获得积分10
38秒前
38秒前
40秒前
41秒前
Chemistry发布了新的文献求助10
45秒前
Dingyiren发布了新的文献求助10
45秒前
wang完成签到,获得积分10
47秒前
Ecc完成签到,获得积分10
49秒前
洋溢完成签到,获得积分10
49秒前
53秒前
龟龟完成签到 ,获得积分10
54秒前
57秒前
涛哥来科研完成签到 ,获得积分10
59秒前
科研通AI2S应助应谷槐采纳,获得10
59秒前
1分钟前
Konradling完成签到,获得积分10
1分钟前
Ecc发布了新的文献求助10
1分钟前
斯文败类应助缓慢天菱采纳,获得10
1分钟前
1分钟前
文献完成签到,获得积分10
1分钟前
Seameng完成签到 ,获得积分10
1分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3146684
求助须知:如何正确求助?哪些是违规求助? 2798001
关于积分的说明 7826352
捐赠科研通 2454503
什么是DOI,文献DOI怎么找? 1306289
科研通“疑难数据库(出版商)”最低求助积分说明 627692
版权声明 601522