Treatment of sleep apnoea early after myocardial infarction with adaptive servo-ventilation – a proof-of-concept randomised controlled trial

医学 心肌梗塞 四分位间距 心脏病学 内科学 临床终点 经皮冠状动脉介入治疗 通风(建筑) 置信区间 随机对照试验 机械工程 工程类
作者
Michael Arzt,Henrik Fox,Stefan Stadler,Andrea Hetzenecker,Olaf Oldenburg,Okka W. Hamer,Florian Poschenrieder,Clemens Wiest,Radu Tanacli,Sebastian Kelle,Leonhard Bruch,Mirko Seidel,Michael Koller,Florian Zeman,Stefan Büchner
出处
期刊:The European respiratory journal [European Respiratory Society]
卷期号:: 2302338-2302338
标识
DOI:10.1183/13993003.02338-2023
摘要

Introduction Sleep-disordered breathing has been associated with less myocardial salvage and smaller infarct size reduction after acute myocardial infarction (AMI). The Treatment of sleep apnoea Early After Myocardial infarction with Adaptive Servo-Ventilation (TEAM-ASV I) trial investigated the effects of adding adaptive servo-ventilation (ASV) for sleep-disordered breathing (SDB) to standard therapy on myocardial salvage index (MSI) and change in infarct size within 12 weeks after AMI. Methods In this multicentre, randomised, open-label trial, patients with AMI and successful percutaneous coronary intervention within 24 h after symptom onset plus SDB (apnoea-hypopnoea index ≥15/h) were randomised to standard medical therapy alone (control) or plus ASV (starting 3.6±1.4 days post-AMI). The primary outcome was MSI at 12 weeks post-AMI. Cardiac magnetic resonance (CMR) imaging was performed at ≤5 days and 12 weeks after AMI. Results Seventy-six individuals were enrolled from February 2014 to August 2020; 39 had complete CMR data for analysis of the primary endpoint. MSI was significantly higher in the ASV versus control group (difference 14.6% of left ventricular mass [LVM]; 95% confidence interval 0.14–29.1; p=0.048). At 12 weeks, absolute [interquartile range] (6.6 [4.8–8.5] versus 2.8 [0.9–4.8] %LVM; p=0.003) and relative (44 [30–57] versus 21 [6–35] % of baseline; p=0.013) reductions in infarct size were greater in the ASV versus control group. No serious treatment-related adverse events occurred. Conclusions : Early treatment of SDB with ASV improved the MSI and decreased the infarct size at 12 weeks after AMI. Larger randomised trials are required to confirm these findings.

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