Mechanochemical synthesis and catalysis of dinuclear Cu (II) complexes in C–S coupling

This study introduces a mechanochemical approach for synthesizing dinuclear Cu (II) complexes and applying them directly in C – S coupling reactions, offering a sustainable alternative to traditional solvent‐based syntheses. The mechanochemical method, recognized for its environmental advantages and efficiency, was employed to synthesize the Cu (II) complex [CuL(μ‐Cl)Cl 2 ] ( I ) and the metal–organic salt 2L . 2[CuCl 4 ] 2− ( II ), thereby minimizing solvent use and waste production. The synthesized complex I exhibited superior catalytic activity in C – S coupling, achieving a 96% yield within 20 min with methanol serving as a grinding medium. The mechanochemical process was further refined and confirmed for its environmental sustainability, with an E‐factor of 0.460 and an EcoScale score of 78. This synthetic method not only shortens reaction times and reduces solvent use but also streamlines the operational procedure, providing a more environmentally benign and economically viable route for C – S coupling. The research highlights the potential of mechanochemistry in simplifying synthetic processes and enhancing their sustainability, paving the way for future advancements in green synthetic strategies.