乙型肝炎表面抗原
医学
内科学
胃肠病学
PEG比率
乙型肝炎病毒
免疫学
聚乙二醇干扰素
慢性肝炎
乙型肝炎
病毒
财务
经济
利巴韦林
作者
Wenxin Wang,Xiaoyan Li,Xueyuan Jin,Rui Jia,Hongmin Wang,Shuang-Nan Zhou,Xin Zhang,Yingying Gao,Fu‐Sheng Wang,Junliang Fu
出处
期刊:iLIVER
日期:2024-07-01
卷期号:: 100107-100107
标识
DOI:10.1016/j.iliver.2024.100107
摘要
To investigate the association between serum IP-10 and HBsAg levels in chronic hepatitis B (CHB) patients previously treated with nucleot(s)ide analogs (NAs) followed by combined treatment with an NA and pegylated interferon alpha (PEG-IFNα). Ninety-nine patients with serum levels of HBsAg < 3000 IU/mL and HBV DNA < 20 IU/mL who received prior NA treatment were enrolled. Participants were administered either NA monotherapy (NA group) or combination therapy with PEG-IFNα (Add-on group). Laboratory indicators and IP-10 levels were assessed in serial peripheral blood samples collected at 12- and 24-week intervals. The outcome of this study was a loss or > 1 log10 IU/mL decline in serum HBsAg. After 48 weeks of antiviral therapy, none of the 27 NA group patients and 15 of the 72 Add-on group patients achieved HBsAg loss. Baseline serum HBsAg and IP-10 levels were equivalent across both groups. The combination treatment led to a decrease in serum HBsAg levels and an early increase in IP-10 levels. Furthermore, a moderate increase in IP-10 levels at weeks 12 or 24 was correlated with loss and decline of HBsAg in the Add-on group. Receiver operating characteristic curve and regression analyses demonstrated that a moderate increase in serum IP-10 levels at weeks 12 or 24 was predictive of HBsAg loss and decline in the Add-on group (P < 0.05). An early and moderate increase in the serum IP-10 level was correlated with responses to PEG-IFNα among patients with CHB treated with NAs.
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