亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Racial and socioeconomic disparities in NSCLC molecular diagnostics uptake

医学 社会经济地位 内科学 婚姻状况 置信区间 优势比 肺癌 队列 流行病学 危险系数 共病 阶段(地层学) 逻辑回归 肿瘤科 环境卫生 人口 生物 古生物学
作者
Stephanie Tuminello,Will R. Turner,Matthew Untalan,Tara Ivic-Pavlicic,Raja M. Flores,Emanuela Taioli
出处
期刊:Journal of the National Cancer Institute [Oxford University Press]
标识
DOI:10.1093/jnci/djae225
摘要

Abstract Background Precision therapies, such as targeted and immunotherapies, have substantially changed the landscape of late-stage non-small cell lung cancer (NSCLC). Yet utilization of these therapies is disproportionate across strata defined by race and socioeconomic status (SES), possibly due to disparities in molecular diagnostic testing (or “biomarker testing”), which is a prerequisite to treatment. Methods We extracted a cohort of NSCLC patients from the Surveillance, Epidemiology and End Results (SEER)-Medicare linked data. The primary outcome was receipt of a molecular diagnostic test, based on claims data. The primary predictors were race and SES. Likelihood of receiving a molecular diagnostic test, and overall survival (OS), were investigated using logistic and Cox proportional hazards regression, adjusted for sex, age, residence, histology, marital status, and comorbidity. Results Of the 28,511 NSCLC patients, 11,209 (39.3%) received molecular diagnostic testing. Compared to White patients, fewer Black patients received a molecular diagnostic test (40.4% vs 27.9%; p < .001). After adjustment, Black patients (ORadj [odds ratio]: 0.64; 95% CI [confidence interval]: 0.58-0.71) and those living in areas with greater poverty (ORadj: 0.85; 95% CI: 0.80-0.89) had statistically significant decreased likelihood of molecular diagnostic testing. Patients who did receive testing had a statistically significant decreased risk of death (HRadj [hazards ratio]: 0.74; 95% CI: 0.72-0.76). These results held in the stratified analysis of stage IV NSCLC patients. Conclusion Disparities exist in comprehensive molecular diagnostics, which is critical for clinical decision making. Addressing barriers to molecular testing could help close gaps in cancer care and improve patient outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
秀丽曼冬发布了新的文献求助10
1秒前
Voldemort完成签到 ,获得积分10
6秒前
grs发布了新的文献求助10
18秒前
秀丽曼冬完成签到,获得积分20
26秒前
暮桉发布了新的文献求助10
39秒前
oscar完成签到,获得积分10
40秒前
41秒前
NexusExplorer应助秀丽曼冬采纳,获得10
43秒前
WANG发布了新的文献求助10
47秒前
53秒前
1分钟前
暮桉完成签到,获得积分10
1分钟前
66发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
一部船完成签到,获得积分10
1分钟前
2分钟前
剑八发布了新的文献求助10
2分钟前
bkagyin应助一部船采纳,获得10
2分钟前
斯文败类应助剑八采纳,获得10
2分钟前
66完成签到,获得积分10
2分钟前
2分钟前
一部船发布了新的文献求助10
2分钟前
kento应助Billy采纳,获得200
2分钟前
2分钟前
wyq关注了科研通微信公众号
2分钟前
胖胖猪完成签到,获得积分10
2分钟前
zhou发布了新的文献求助10
3分钟前
刘敏完成签到 ,获得积分10
3分钟前
3分钟前
3分钟前
追寻的宛er完成签到 ,获得积分10
3分钟前
yeyi9851应助科研通管家采纳,获得10
3分钟前
StellaZhang完成签到 ,获得积分10
3分钟前
风花雪月完成签到 ,获得积分10
3分钟前
Billy应助GeoEye采纳,获得10
3分钟前
Sanci完成签到,获得积分10
4分钟前
Sanci发布了新的文献求助10
4分钟前
4分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
New China Forges Ahead: Important Documents of the Third Session of the First National Committee of the Chinese People's Political Consultative Conference 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056448
求助须知:如何正确求助?哪些是违规求助? 2713056
关于积分的说明 7434445
捐赠科研通 2358100
什么是DOI,文献DOI怎么找? 1249233
科研通“疑难数据库(出版商)”最低求助积分说明 606992
版权声明 596195