To find the optimal equipment configuration for the earthwork construction in the upper reservoir of pumped storage power stations, the discrete event simulation was combined with the multi-objective optimization to optimize the construction equipment configurations of the upper reservoir in this paper. According to the daily filling intensity, different types and numbers of equipment were combined and the daily construction time of various combinations was calculated through simulation. Then, the equipment costs and carbon emissions were calculated by a multi-objective model. Setting different weights for each objective to consider the decision preferences of decision-makers, the optimal equipment configuration of earthwork construction was obtained by the multi-objective decision. This optimization framework was applied to a reservoir engineering in karst depressions, the results show that different preferences have an impact on the decision of optimal schemes. At the same time, the obtained schemes show low average queuing trucks and road congestions, and a high utilization rate of the equipment.