Effect of BMI on patients undergoing transcatheter aortic valve implantation: A systematic review and meta-analysis

医学 体重不足 优势比 荟萃分析 超重 内科学 体质指数 置信区间 血脂异常 肥胖 肥胖悖论 科克伦图书馆 心脏病学
作者
Rahul Gupta,Elham Mahmoudi,Amir Hossein Behnoush,Amirmohammad Khalaji,Aaqib H. Malik,Aayushi Sood,Dhrubajyoti Bandyopadhyay,Syed Zaid,Akshay Goel,Jayakumar Sreenivasan,Chirdeep Patel,Apurva Vyas,Carl J. Lavie,Nainesh Patel
出处
期刊:Progress in Cardiovascular Diseases [Elsevier BV]
卷期号:78: 58-66 被引量:12
标识
DOI:10.1016/j.pcad.2022.12.006
摘要

The relationship of body mass index (BMI) and an “obesity paradox” with cardiovascular risk prediction is controversial. This systematic review and meta-analysis aims to compare the associations of different BMI ranges on transcatheter aortic valve implantation (TAVI) outcomes. International databases, including PubMed, the Web of Science, and the Cochrane Library, were systematically searched for observational and randomized controlled trial studies investigating TAVI outcomes in any of the four BMI categories: underweight, normal weight, overweight, and obese with one of the predefined outcomes. Primary outcomes were in-hospital, 30-day, and long-term all-cause mortality. Random-effects meta-analysis was performed to calculate the odds ratio (OR) or standardized mean differences (SMD) with 95% confidence interval (CI) for each paired comparison between two of the BMI categories. A total of 38 studies were included in our analysis, investigating 99,829 patients undergoing TAVI. There was a trend toward higher comorbidities such as hypertension, diabetes, and dyslipidemia in overweight patients and individuals with obesity. Compared with normal-weight, patients with obesity had a lower rate of 30-day mortality (OR 0.42, 95% CI 0.25–0.72, p < 0.01), paravalvular aortic regurgitation (OR 0.63, 95% CI 0.44–0.91, p = 0.01), 1-year mortality (OR 0.48, 95% CI 0.24–0.96, p = 0.04), and long-term mortality (OR 0.69, 95% CI 0.51–0.94, p = 0.02). However, acute kidney injury (OR 1.16, 95% CI 1.04–1.30, p = 0.01) and permanent pacemaker implantation (OR 1.25, 95% CI 1.05–1.50, p = 0.01) odds were higher in patients with obesity. Noteworthy, major vascular complications were significantly higher in underweight patients in comparison with normal weight cases (OR 1.62, 95% CI 1.07–2.46, p = 0.02). In terms of left ventricular ejection fraction (LVEF), patients with obesity had higher post-operative LVEF compared to normal-weight individuals (SMD 0.12, 95% CI 0.02–0.22, p = 0.02). Our results suggest the presence of the “obesity paradox” in TAVI outcomes with higher BMI ranges being associated with lower short- and long-term mortality. BMI can be utilized for risk prediction of patients undergoing TAVI.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
koial完成签到 ,获得积分10
1秒前
沐晴发布了新的文献求助30
2秒前
独特的翠芙完成签到,获得积分10
2秒前
111发布了新的文献求助10
3秒前
科目三应助灵巧冰绿采纳,获得10
3秒前
4秒前
高速旋转老沁完成签到 ,获得积分10
4秒前
情怀应助李双兔采纳,获得10
4秒前
yu5546完成签到,获得积分10
5秒前
6秒前
积极烧鹅发布了新的文献求助10
6秒前
6秒前
丘比特应助等待半烟采纳,获得10
6秒前
毛毛发布了新的文献求助10
7秒前
7秒前
CHENCHEN完成签到,获得积分10
7秒前
8秒前
yu5546发布了新的文献求助10
8秒前
8秒前
8秒前
8秒前
买米当卡消失术完成签到,获得积分10
10秒前
小马甲应助搞学术的采纳,获得10
10秒前
优美的契完成签到,获得积分10
10秒前
西瓜完成签到,获得积分10
11秒前
GQ发布了新的文献求助10
11秒前
大模型应助wucl1990采纳,获得10
11秒前
111完成签到,获得积分20
12秒前
erhao发布了新的文献求助10
12秒前
南柯一梦发布了新的文献求助10
12秒前
二掌柜发布了新的文献求助10
12秒前
李李发布了新的文献求助10
12秒前
春来完成签到,获得积分20
12秒前
13秒前
荔枝柚子发布了新的文献求助10
15秒前
15秒前
孙燕应助欣喜聪健采纳,获得50
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988786
求助须知:如何正确求助?哪些是违规求助? 3531116
关于积分的说明 11252493
捐赠科研通 3269766
什么是DOI,文献DOI怎么找? 1804771
邀请新用户注册赠送积分活动 881870
科研通“疑难数据库(出版商)”最低求助积分说明 809021