Phosphonamidates of Camphorsultam: Versatile Building Blocks for the Synthesis of <i>P</i>‐Chiral Phosphorous(V) Compounds

Camphorsultam was utilized for the optical resolution of <i>P</i>‐chiral phosphorous compounds. After chromatographic separation of diastereomeric <i>R</i>_P‐ and <i>S</i>_P‐ phosphonamidate intermediates, subsequent substitution reactions with phenol derivatives yielded <i>P</i>‐chiral phosphonic acid aryl esters with excellent enantioselectivities. In these processes, chiral sulfonamide of camphorsultam demonstrated superior abilities as an optical‐resolving agent and a good leaving group. This method was applied to the synthesis of <i>P</i>‐chiral phosphinic esters, phosphonamidates, and thiophosphonate diesters.