亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Short term complications of conisation and long term effects on fertility related outcomes in Denmark: register based nationwide cohort study

期限(时间) 语域(社会语言学) 生育率 医学 队列 队列研究 儿科 人口学 环境卫生 内科学 人口 哲学 语言学 物理 量子力学 社会学
作者
Mathias Aagaard,Jessica á Rogvi,Frederikke Agerbo Modin,Dagný Rós Nicolaisdóttir,Volkert Siersma,John Brodersen
标识
DOI:10.1136/bmj-2023-078140
摘要

Abstract Objective To report on complications of conisation and its effects on fertility and stenosis. Design Register based nationwide cohort study on routinely collected data using several linked databases. Setting Primary and secondary care in Denmark, 2006-18. Population The conisation cohort comprised 48 048 conisations on women aged 23-65 who had undergone conisation within 120 days of a cervical biopsy. The biopsy cohort comprised 48 048 biopsies on women who had undergone a cervical biopsy but not conisation who were matched by age and time of procedure. Women were excluded from the conisation cohort before long term outcome analyses if they had undergone hysterectomy, resection of the uterus, or had cervical cancer or any long term outcomes within the 10 years before their conisation. Main outcome measures Bleeding, infection, and gynaecological operations within 30 days of conisation (stratified by age, year of conisation, and number of previous conisations) and long term risk of fertility treatment, fertility consultation, stenosis, cervical dilatation, infertility diagnoses, and death at any point after conisation. Long term outcomes were followed up until death, emigration, diagnosis of cervical cancer, hysterectomy or resection of uterus, or the end of 2018. Long term outcomes were analysed with incidence rate ratios from Cox regression models. Results Bleeding, infection, and gynaecological operations were registered for 2.81% (n=1351), 0.48% (n=231), and 3.95% (n=1897) of all conisations within 30 days of the procedure, respectively. Women in the conisation cohort had increased risk of stenosis (incidence rate ratio 14.81, 95% confidence interval 7.55 to 29.05, 0.41% v 0.03% (n=176 v 12)) and cervical dilatation (2.68, 2.41 to 2.97, 4.01% v 1.58% (n=1735 v 668)) compared with women in the biopsy cohort. No significant differences were observed for the other outcomes when adjusting for baseline covariates (such as age and region of residence). Cervical suturing after bleeding was associated with a substantial increase in the risk of stenosis and cervical dilatation. Conclusion This study found higher rates of complications within 30 days of conisation than previous studies with comparable outcome definitions, and a substantially increased risk of stenosis and cervical dilatation for women who had cervical suturing to treat bleeding after conisation. However, these results were based on few events in a small subgroup, and are therefore associated with major uncertainty. This study supports previous findings that conisation does not generally increase rates of infertility treatment or infertility diagnoses.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
10秒前
Polymer72应助科研通管家采纳,获得10
23秒前
Polymer72应助科研通管家采纳,获得10
24秒前
Polymer72应助科研通管家采纳,获得10
24秒前
Polymer72应助科研通管家采纳,获得10
24秒前
米糖安发布了新的文献求助10
27秒前
lisaltp完成签到,获得积分10
56秒前
米糖安完成签到,获得积分10
1分钟前
xinqianying完成签到 ,获得积分10
1分钟前
iris完成签到,获得积分20
1分钟前
DrleedsG完成签到,获得积分10
1分钟前
2分钟前
Polymer72应助科研通管家采纳,获得10
2分钟前
Polymer72应助科研通管家采纳,获得10
2分钟前
2分钟前
3分钟前
3分钟前
重要元灵完成签到 ,获得积分10
3分钟前
吾系渣渣辉完成签到 ,获得积分10
3分钟前
3分钟前
3分钟前
Polymer72完成签到,获得积分0
3分钟前
黑球发布了新的文献求助10
4分钟前
Tethys完成签到 ,获得积分10
4分钟前
黑球完成签到,获得积分10
4分钟前
Polymer72应助科研通管家采纳,获得10
4分钟前
4分钟前
ght完成签到 ,获得积分10
4分钟前
5分钟前
5分钟前
5分钟前
He发布了新的文献求助10
5分钟前
He发布了新的文献求助10
5分钟前
He发布了新的文献求助10
5分钟前
CSun完成签到,获得积分10
5分钟前
CSun发布了新的文献求助10
5分钟前
高兴凝安完成签到 ,获得积分10
5分钟前
Polymer72应助科研通管家采纳,获得10
6分钟前
Polymer72应助科研通管家采纳,获得10
6分钟前
Polymer72应助科研通管家采纳,获得10
6分钟前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1200
RNAの科学 ―時代を拓く生体分子― 金井 昭夫(編) 1000
BIOLOGY OF NON-CHORDATES 1000
进口的时尚——14世纪东方丝绸与意大利艺术 Imported Fashion:Oriental Silks and Italian Arts in the 14th Century 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 550
Education and Upward Social Mobility in China: Imagining Positive Sociology with Bourdieu 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3353504
求助须知:如何正确求助?哪些是违规求助? 2978145
关于积分的说明 8683813
捐赠科研通 2659514
什么是DOI,文献DOI怎么找? 1456277
科研通“疑难数据库(出版商)”最低求助积分说明 674310
邀请新用户注册赠送积分活动 665020