The Interaction and Mediation of Physical Activity of Body Mass Index with Cardiovascular Disease: evidence from NHANES and MR Analysis

体质指数 医学 混淆 调解 优势比 全国健康与营养检查调查 孟德尔随机化 置信区间 内科学 人口学 疾病 环境卫生 人口 社会学 生物化学 化学 遗传变异 政治学 基因型 法学 基因
作者
Liang Zhao,Danfeng Zhang,Faming Zhang,Chu Wang,Shuo Han,Tengfei Zhang,Zhiqing He,J.G. Wang
出处
期刊:Medicine and Science in Sports and Exercise [Lippincott Williams & Wilkins]
标识
DOI:10.1249/mss.0000000000003668
摘要

ABSTRACT Background Both insufficient physical activity (PA) and excess body weight are important risk factors for cardiovascular disease (CVD), and PA is closely related to body weight. However, it remains unclear whether PA modifies or mediates the association of body mass index (BMI) with CVD. Methods We conducted a cross-sectional study of 35,406 adults participating in the National Health and Nutrition Examination Survey (NHANES). The mediation and interaction effects of PA were assessed using a four-way decomposition approach. An additional two-step Mendelian randomization (MR) analysis was performed to verify the potential causal mediation effect. Results A strong association was observed between PA and lower odds of CVD after adjusting for all confounders [Odds Ratio (OR): 0.84; 95% Confidence Interval (CI): 0.74–0.95]. Increased BMI was associated with higher odds of CVD (OR: 1.04; 95% CI: 1.03–1.04). PA showed interaction and mediation effects on the association of BMI with CVD. The overall proportion attributable to interaction was -37.5%, while the overall proportion attributable to mediation was 22.2%. MR analysis further confirmed that PA causally mediated the pathway from BMI to CVD. Conclusions PA modified the association of BMI with CVD, suggesting that sufficient PA is needed to lower the impact of high BMI on CVD risk. Moreover, we found that PA served as a causal influence on the association of BMI with CVD, indicating that higher BMI led to a lower level of PA, which in turn increased the risk of CVD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
英姑应助哈哈哈采纳,获得10
1秒前
1秒前
热情大树发布了新的文献求助10
1秒前
2秒前
wmw发布了新的文献求助10
2秒前
JM关闭了JM文献求助
3秒前
3秒前
锥锥完成签到,获得积分10
3秒前
hzz发布了新的文献求助10
3秒前
3秒前
3秒前
hy完成签到,获得积分10
4秒前
CodeCraft应助ysy采纳,获得10
4秒前
4秒前
jj发布了新的文献求助10
4秒前
赘婿应助邢丹丹采纳,获得10
4秒前
5秒前
miaomiao发布了新的文献求助10
5秒前
5秒前
6秒前
cx330发布了新的文献求助10
6秒前
7秒前
7秒前
8秒前
CodeCraft应助千纸鹤采纳,获得10
8秒前
Wang完成签到,获得积分10
8秒前
CipherSage应助幼汁汁鬼鬼采纳,获得10
10秒前
10秒前
Dopamine发布了新的文献求助10
10秒前
景行行止发布了新的文献求助10
10秒前
纷纭完成签到,获得积分10
11秒前
freedom发布了新的文献求助10
11秒前
学术蝗虫2726完成签到,获得积分10
11秒前
12秒前
Glacier发布了新的文献求助10
12秒前
昏睡的蟠桃应助derder采纳,获得100
12秒前
平常的狗应助jj采纳,获得10
12秒前
chenlichan发布了新的文献求助10
12秒前
water完成签到,获得积分10
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974463
求助须知:如何正确求助?哪些是违规求助? 3518823
关于积分的说明 11196212
捐赠科研通 3255008
什么是DOI,文献DOI怎么找? 1797655
邀请新用户注册赠送积分活动 877052
科研通“疑难数据库(出版商)”最低求助积分说明 806130