Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong

糖尿病前期 医学 糖尿病 优势比 队列 流行病学 队列研究 纵向研究 老年学 环境卫生 2型糖尿病 人口学 内科学 内分泌学 病理 社会学
作者
Yuanyuan Yi,Cui Guo,Yiling Zheng,Siyi Chen,Changqing Lin,Alexis K.H. Lau,Martin C. S. Wong,David Bishai
出处
期刊:Diabetes Care [American Diabetes Association]
标识
DOI:10.2337/dc24-1041
摘要

OBJECTIVE Both air pollution and diabetes are key urban challenges. The association between particulate matter with a diameter of <2.5 μm (PM2.5) exposure and prediabetes/diabetes in adults is well documented, but the health effects of life course exposure remain unclear. This study evaluated the impact of PM2.5 exposure throughout various life stages on the prevalence of prediabetes/diabetes in adulthood. RESEARCH DESIGN AND METHODS We included 4,551 individuals with 19,593 medical visits from two open cohorts in Taiwan and Hong Kong between 2000 and 2018. Ambient PM2.5 exposure was assessed using a satellite-based model, delivering a 2-year average exposure at a resolution of 1 km2. Logistic mixed-effects models were used to investigate longitudinal associations between PM2.5 exposure and the prevalence of prediabetes/diabetes. Life course models were used to examine the impact of PM2.5 exposure at different life stages on prediabetes/diabetes in adulthood. RESULTS Over an average follow-up period of 9.93 years, 1,660 individuals with prediabetes/diabetes were observed. For the longitudinal association, every 10 μg/m3 increase in PM2.5 was associated with an increased odds of having prediabetes/diabetes (odds ratio 1.32, 95% CI 1.13, 1.54). The odds of adulthood prediabetes/diabetes increased by 15%, 18%, and 29% for each 10 μg/m3 increase in PM2.5 exposure during school age, adolescence, and adulthood, respectively. CONCLUSIONS Our findings suggest a link between PM2.5 exposure during each life stage and the prevalence of prediabetes/diabetes in adulthood, with the health impacts of exposure during adulthood being slightly greater. This study underscores the need for life course air pollution control strategies to mitigate the substantial disease burden of diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
超体完成签到 ,获得积分10
2秒前
SYT完成签到,获得积分10
3秒前
失眠的之桃完成签到 ,获得积分10
3秒前
花花发布了新的文献求助10
4秒前
懒得起名发布了新的文献求助10
5秒前
orixero应助Dawn采纳,获得10
5秒前
whale发布了新的文献求助20
5秒前
6秒前
6秒前
Helium完成签到,获得积分10
6秒前
小星星668完成签到,获得积分10
7秒前
8秒前
晴悦完成签到,获得积分10
10秒前
10秒前
10秒前
11秒前
fiona完成签到,获得积分10
12秒前
PaoPao发布了新的文献求助10
12秒前
¥#¥-11发布了新的文献求助10
12秒前
科研通AI5应助和花花采纳,获得10
12秒前
yellow完成签到 ,获得积分10
12秒前
13秒前
晴悦发布了新的文献求助10
13秒前
13秒前
Owen应助xiao.yang采纳,获得10
13秒前
谨慎飞丹完成签到 ,获得积分10
15秒前
Jeffrey完成签到,获得积分10
15秒前
dropwater完成签到,获得积分10
16秒前
牧析山发布了新的文献求助10
16秒前
16秒前
MHJJJ发布了新的文献求助30
16秒前
微笑完成签到,获得积分10
17秒前
闪闪纸飞机完成签到,获得积分10
17秒前
18秒前
Nextone完成签到,获得积分10
18秒前
赘婿应助疯狂的小蘑菇采纳,获得30
19秒前
123完成签到,获得积分10
19秒前
Akim应助niekyang采纳,获得10
19秒前
实验室扛把子完成签到,获得积分10
20秒前
高分求助中
Comparative Anatomy of the Vertebrates 9th 3000
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3571872
求助须知:如何正确求助?哪些是违规求助? 3142287
关于积分的说明 9446687
捐赠科研通 2843683
什么是DOI,文献DOI怎么找? 1562971
邀请新用户注册赠送积分活动 731530
科研通“疑难数据库(出版商)”最低求助积分说明 718557