The Utility of the PTeye Autofluorescence Detection Device During Parathyroidectomy for the Treatment of Primary Hyperparathyroidism

ABSTRACT Background This study evaluates the utility of PTeye autofluorescence (AF) technology in primary hyperparathyroidism (PHPT) surgery. Methods A retrospective review analyzed 232 patients undergoing first‐time parathyroid surgery between September 2021 and 2023. Of these, 92 underwent surgery consecutively without PTeye assistance, then 140 underwent PTeye‐guided surgery consecutively. Results The PTeye‐guided surgery group showed significantly higher parathyroid gland identification rates ( p < 0.001) and a 20.7 times greater likelihood of identifying all four glands compared to controls (3.3%). No cases of permanent hypoparathyroidism were reported, indicating the procedure's safety. Conclusions PTeye appears to be a safe and effective technology that can be used to improve parathyroid gland identification during first time surgery for PHPT. This is particularly beneficial for patient population with a high prevalence of multiglandular disease.