作者
Sumit Gupta,Rachel E. Rau,John A. Kairalla,Karen R. Rabin,Cindy Wang,Anne Angiolillo,Sarah Alexander,Andrew J. Carroll,Susan J. Conway,Lia Gore,Ilan Kirsch,Holly R. Kubaney,Amanda M. Li,Jennifer L. McNeer,Olga Militano,Tamara P. Miller,Yvonne Moyer,Maureen M. O’Brien,Maki Okada,Shalini C. Reshmi,Mary Shago,Elizabeth M. Wagner,Naomi J. Winick,Brent L. Wood,Tara Haworth-Wright,Faraz Zaman,Gerhard Zugmaier,Sue Zupanec,Meenakshi Devidas,Stephen P. Hunger,David T. Teachey,Elizabeth A. Raetz,Mignon L. Loh
摘要
B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among children. The addition of the bispecific T-cell engager molecule blinatumomab (an anti-CD19 and anti-CD3 single-chain molecule) to therapy for newly diagnosed standard-risk (as defined by the National Cancer Institute) B-cell ALL in children may improve outcomes.