Differential effects of sleep deprivation on behavior and microglia in a brain-region-specific manner in young and aged male mice

小胶质细胞 低能 前额叶皮质 海马体 内分泌学 伏隔核 中枢神经系统 内科学 睡眠剥夺 扁桃形结构 神经科学 CX3CR1型 生物 心理学 医学 炎症 趋化因子 昼夜节律 认知 趋化因子受体
作者
Rong‐Jun Ni,Sheng Wang,Wen‐Jun Pu,Yingying Wei,Jinxue Wei,Liansheng Zhao,Xiaohong Ma
出处
期刊:Brain Behavior and Immunity [Elsevier]
卷期号:117: 12-19 被引量:4
标识
DOI:10.1016/j.bbi.2023.12.031
摘要

Microglia, resident immune cells in the central nervous system, constantly monitor the state of the surrounding brain activity. The animal model induced by sleep deprivation (SD) is widely used to study the pathophysiological mechanisms of insomnia and bipolar disorder. However, it remains unclear whether SD affects behaviors in young and aged male mice and microglia in various brain regions. In this study, we confirmed brain region-specific changes in microglial density and morphology in the accumbens nucleus (Acb), amygdala (AMY), cerebellum (Cb), corpus callosum (cc), caudate putamen, hippocampus (HIP), hypothalamus (HYP), medial prefrontal cortex (mPFC), and thalamus (TH) of young mice. In addition, the density of microglia in old mice was higher than that in young mice. Compared with young mice, old mice showed a markedly increased microglial size, decreased total length of microglial processes, and decreased maximum length. Importantly, we found that 48-h SD decreased microglial density and morphology in old mice, whereas SD increased microglial density and morphology in most observed brain regions in young mice. SD-induced hyperactivity was observed only in young mice but not in old mice. Moreover, microglial density (HIP, AMY, mPFC, CPu) was significantly positively correlated with behaviors in SD- and vehicle-treated young mice. Contrarily, negative correlations were shown between the microglial density (cc, Cb, TH, HYP, Acb, AMY) and behaviors in vehicle-treated young and old mice. These results suggest that SD dysregulates the homeostatic state of microglia in a region- and age-dependent manner. Microglia may be involved in regulating age-related behavioral responses to SD.
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