特应性皮炎
金黄色葡萄球菌
微生物群
疾病
免疫学
医学
皮肤屏障
皮肤病科
生物
生物信息学
细菌
病理
遗传学
作者
Teruaki Nakatsuji,Alexander R. Horswill
标识
DOI:10.1016/j.jid.2024.01.001
摘要
Pruritus or itch is a defining symptom of atopic dermatitis (AD). The origins of itch are complex, and it is considered both a defense mechanism and a cause of disease that leads to inflammation and psychological stress. Considerable progress has been made in understanding the processes that trigger itch, particularly the pruritoceptive origins that are generated in the skin. This perspective review discusses the implications of a recent observation that the V8 protease expressed by Staphylococcus aureus can directly trigger sensory neurons in the skin through activation of protease-activated receptor 1. This may be a key to understanding why itch is so common in AD because S. aureus commonly overgrows in this disease owing to deficient antimicrobial defense from both the epidermis and the cutaneous microbiome. Increased understanding of the role of microbes in AD provides increased opportunities for safely improving the treatment of this disorder.
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