Abnormal metabolism in hepatic stellate cells: Pandora's box of MAFLD related hepatocellular carcinoma

肝星状细胞 肝细胞癌 免疫系统 肝癌 癌变 癌症研究 肝损伤 肝病 肿瘤微环境 癌症 肝硬化 脂肪肝 医学 生物 内科学 疾病 免疫学 病理
作者
Yuan-dong Sun,Hao Zhang,Yuanmin Li,Jianjun Han
出处
期刊:Biochimica Et Biophysica Acta - Reviews On Cancer [Elsevier]
卷期号:1879 (2): 189086-189086 被引量:4
标识
DOI:10.1016/j.bbcan.2024.189086
摘要

Metabolic associated fatty liver disease (MAFLD) is a significant risk factor for the development of hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs), as key mediators in liver injury response, are believed to play a crucial role in the repair process of liver injury. However, in MAFLD patients, the normal metabolic and immunoregulatory mechanisms of HSCs become disrupted, leading to disturbances in the local microenvironment. Abnormally activated HSCs are heavily involved in the initiation and progression of HCC. The metabolic disorders and abnormal activation of HSCs not only initiate liver fibrosis but also contribute to carcinogenesis. In this review, we provide an overview of recent research progress on the relationship between the abnormal metabolism of HSCs and the local immune system in the liver, elucidating the mechanisms of immune imbalance caused by abnormally activated HSCs in MAFLD patients. Based on this understanding, we discuss the potential and challenges of metabolic-based and immunology-based mechanisms in the treatment of MAFLD-related HCC, with a specific focus on the role of HSCs in HCC progression and their potential as targets for anti-cancer therapy. This review aims to enhance researchers' understanding of the importance of HSCs in maintaining normal liver function and highlights the significance of HSCs in the progression of MAFLD-related HCC.
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