Microfluidic Generation of Diverse Lipid Nanoparticle Libraries

图书馆学 计算生物学 纳米技术 计算机科学 生物 材料科学
作者
Andrew R. Hanna,Sarah J. Shepherd,David Issadore,Michael J. Mitchell
出处
期刊:Nanomedicine [Future Medicine]
卷期号:19 (6): 455-457 被引量:1
标识
DOI:10.2217/nnm-2023-0345
摘要

NanomedicineVol. 19, No. 6 EditorialMicrofluidic generation of diverse lipid nanoparticle librariesAndrew R Hanna, Sarah J Shepherd, David Issadore & Michael J MitchellAndrew R Hanna https://orcid.org/0009-0009-3220-4378Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA, Sarah J ShepherdDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA, David Issadore*Author for correspondence: E-mail Address: issadore@seas.upenn.eduDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA & Michael J Mitchell **Author for correspondence: E-mail Address: mjmitch@seas.upenn.eduhttps://orcid.org/0000-0002-3628-2244Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USAPenn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAPublished Online:19 Jan 2024https://doi.org/10.2217/nnm-2023-0345AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: drug deliveryhigh-throughput screeninglipid nanoparticlesmicrofluidicstissue targetingReferences1. 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Microfluidic technologies for accelerating the clinical translation of nanoparticles. Nat. Nanotechnol. 7(10), 623–629 (2012).Medline CASGoogle Scholar7. Shepherd SJ, Issadore D, Mitchell MJ. Microfluidic formulation of nanoparticles for biomedical applications. Biomaterials 274, 120826 (2021).Medline CASGoogle Scholar8. Stroock AD, Dertinger SKW, Ajdari A, Mezić I, Stone HA, Whitesides GM. Chaotic mixer for microchannels. Science 295(5555), 647–651 (2002).Medline CASGoogle Scholar9. Shepherd SJ, Han X, Mukalel AJ et al. Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Proc. Natl Acad. Sci. 120(33), e2303567120 (2023).Medline CASGoogle Scholar10. Gindy ME, DiFelice K, Kumar V et al. Mechanism of macromolecular structure evolution in self-assembled lipid nanoparticles for siRNA delivery. Langmuir 30(16), 4613–4622 (2014).Medline CASGoogle Scholar11. O'Brien Laramy MN, Costa AP, Cebrero YM et al. Process robustness in lipid nanoparticle production: a comparison of microfluidic and turbulent jet mixing. Mol. Pharm. 20(8), 4285–4296 (2023).MedlineGoogle Scholar12. Dahlman JE, Kauffman KJ, Xing Y et al. Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Proc. Natl Acad. Sci. 114(8), 2060–2065 (2017).Medline CASGoogle Scholar13. Leung AKK, Hafez IM, Baoukina S et al. Lipid nanoparticles containing siRNA synthesized by microfluidic mixing exhibit an electron-dense nanostructured core. J. Phys. Chem. C. 116(34), 18440–18450 (2012).CASGoogle Scholar14. Reker D, Rybakova Y, Kirtane AR et al. Computationally guided high-throughput design of self-assembling drug nanoparticles. Nat. Nanotechnol. 16(6), 725–733 (2021).Medline CASGoogle Scholar15. Kumar R, Le N, Tan Z, Brown ME, Jiang S, Reineke TM. Efficient polymer-mediated delivery of gene-editing ribonucleoprotein payloads through combinatorial design, parallelized experimentation, and machine learning. ACS Nano 14(12), 17626–17639 (2020).Medline CASGoogle Scholar16. Sunscreen - LNP Formulation Screening. Unchained Labs (2023). Available from: www.unchainedlabs.com/sunscreen/ (Accessed 13 November 2023).Google Scholar17. Götz J, Jackl MK, Jindakun C et al. High-throughput synthesis provides data for predicting molecular properties and reaction success. Sci. Adv. 9(43), eadj2314 (2023).Medline CASGoogle Scholar18. Rhym LH, Manan RS, Koller A, Stephanie G, Anderson DG. Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery. Nat. Biomed. Eng. 7(7), 901–910 (2023).Medline CASGoogle Scholar19. Kimura N, Maeki M, Sato Y et al. Development of a microfluidic-based post-treatment process for size-controlled lipid nanoparticles and application to siRNA delivery. ACS Appl. Mater. Interfaces 12(30), 34011–34020 (2020).Medline CASGoogle Scholar20. Cruz-Samperio R, Hicks CL, Scott A et al. Modular bioorthogonal lipid nanoparticle modification platforms for cardiac homing. J. Am. Chem. Soc. 145(41), 22659–22670 (2023).Medline CASGoogle ScholarFiguresReferencesRelatedDetails Vol. 19, No. 6 STAY CONNECTED Metrics Downloaded 266 times History Received 24 November 2023 Accepted 6 December 2023 Published online 19 January 2024 Published in print March 2024 Information© 2024 Expert Publishing Medicine Ltd trading as Taylor & FrancisKeywordsdrug deliveryhigh-throughput screeninglipid nanoparticlesmicrofluidicstissue targetingFinancial disclosureMJ Mitchell acknowledges financial support from the NIH, grant number DP2TR002776. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Writing disclosureNo writing assistance was utilized in the production of this manuscript.Competing interests disclosureThe authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.PDF download
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