血栓形成
医学
氧化应激
锡尔图因
凝结
血小板活化
血小板
发病机制
体内
免疫学
生物信息学
NAD+激酶
药理学
生物
内科学
生物化学
酶
遗传学
作者
Alessandra Bettiol,Maria Letizia Urban,Giacomo Emmi,Silvia Galora,Flavia Rita Argento,Eleonora Fini,Serena Borghi,Giacomo Bagni,Irene Mattioli,Domenico Prisco,Claudia Fiorillo,Matteo Becatti
标识
DOI:10.3389/fmolb.2023.1325002
摘要
Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and coagulation. Furthermore, SIRT1 displays anti-inflammatory activity both in vitro , in vivo and in clinical studies, particularly via the reduction of oxidative stress. On these bases, several studies have investigated the therapeutic potential of targeting SIRT1 for the prevention of thrombosis. This review provides a comprehensive and critical overview of the main preclinical and clinical studies and of the current understanding of the role of SIRT1 in thrombosis.
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