Polyoxometalate‐Nanozyme‐Integrated Nanomotors (POMotors) for Self‐Propulsion‐Promoted Synergistic Photothermal‐Catalytic Tumor Therapy

Enzyme‐powered nanomotors have demonstrated promising potentials in biomedical applications, especially for catalytic tumor therapy, owing to their ability of self‐propulsion and bio‐catalysis. However, the fragility of natural enzymes limits their environmental adaptability and also therapeutic efficacy in catalysis enabled tumor therapy. Herein, polyoxometalate nanozyme‐based light‐driven nanomotors were designed and synthesized for targeted synergistic photothermal‐catalytic tumor therapy. In this construct, the peroxidase‐like activity of the P2W18Fe4 polyoxometalates‐based nanomotors can provide self‐propulsion and facilitate their production of reactive oxygen species thus killing tumor cells, even in the weakly acidic tumor microenvironment. Conjugated polydopamine endows the nanomotors with capability of light‐driven self‐propulsion behavior. After 10 min of NIR (808 nm) irradiation, along with the help of epidermal growth factor receptor antibody, the targeted accumulation and penetration of nanomotors in the tumor enabled highly efficient synergistic photothermal‐catalytic therapy. This approach overcomes the disadvantages of the intrinsic fragile nature of enzyme‐powered nanomotors in physiological environments, and more importantly, providing a motility‐behavior promoted synergistic anti‐tumor strategy.