SO2-Extrusive 1,4-(Het)Aryl Migration: Synthesis of α-Aryl Amides and Related Reactions

Abstract (Het)aryl migration has emerged as a key synthetic tool and has particularly been exploited for the synthesis of α-aryl amides. This method overcomes the existing α-arylation methods, which are not always compatible with the introduction of (het)aryl groups possessing bulky or electrophilic substituents. This review focuses on SO2-extrusive (het)aryl migration in the frame of α-aryl amide synthesis. Anion- and radical-mediated transformations are reported, including the synthesis of polycyclic compounds through cascade reactions. 1 Introduction 2 Anionic Aryl Migration 3 Radical Aryl Migration 4 Conclusion