微生物群
失调
发病机制
基因组
抗生素耐药性
抗生素
生物
免疫学
微生物学
生物信息学
基因
遗传学
作者
Jiani Wu,Wei Liu,Lin Zhu,Nina Li,Geng-yan Luo,Ming Gu,Min-Wu Peng,Shike Zeng,Shu Wu,Shengze Zhang,Qiqi Chen,Meiqi Cai,Wei Cao,Ying Jiang,Chuming Luo,Dechao Tian,Mǎng Shī,Yuelong Shu,Guohui Chang,Huanle Luo
摘要
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is ongoing and multiple studies have elucidated its pathogenesis, however, the related- microbiome imbalance caused by SARS-CoV-2 is still not clear. In this study, we have comprehensively compared the microbiome composition and associated function alterations in the oropharyngeal swabs of healthy controls and coronavirus disease 2019 (COVID-19) patients with moderate or severe symptoms by metatranscriptomic sequencing. We did observe a reduced microbiome alpha-diversity but significant enrichment of opportunistic microorganisms in patients with COVID-19 compared with healthy controls, and the microbial homeostasis was rebuilt following the recovery of COVID-19 patients. Correspondingly, less functional genes in multiple biological processes and weakened metabolic pathways such as carbohydrate metabolism, energy metabolism were also observed in COVID-19 patients. We only found higher relative abundance of limited genera such as Lachnoanaerobaculum between severe patients and moderate patients while no worthy-noting microbiome diversity and function alteration were observed. Finally, we noticed that the co-occurrence of antibiotic resistance and virulence was closely related to the microbiome alteration caused by SRAS-CoV-2. Overall, our findings demonstrate that microbial dysbiosis may enhance the pathogenesis of SARS-CoV-2 and the antibiotics treatment should be critically considered.
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