清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Understanding the role of chronopharmacology for drug optimization: what do we know?

时辰疗法(睡眠期) 医学 重症监护医学 药品 药物治疗 药效学 药理学 临床实习 昼夜节律 药代动力学 内科学 物理疗法
作者
Akio Fujimura,K. Ushijima
出处
期刊:Expert Review of Clinical Pharmacology [Taylor & Francis]
卷期号:16 (7): 655-668 被引量:8
标识
DOI:10.1080/17512433.2023.2233438
摘要

ABSTRACTABSTRACTIntroduction Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a number of drugs and affects their therapeutic efficacy and toxicity depending on the time of day they are administered. Chronopharmacology is a method for incorporating knowledge about circadian rhythm into pharmacotherapy. Chronotherapy, which is the clinical application of chronopharmacology, is particularly relevant when the risk and/or severity of symptoms of a disease change in a predictable manner over time. Chronotherapy has potential benefits in the treatment of many diseases.Areas covered Although a considerable amount of knowledge about chronopharmacology and chronotherapy has been accumulated, its therapeutic application in clinical practice remains limited in terms of therapy optimization. Resolution of these issues will improve our ability to deliver adequate drug treatment.Expert opinion We propose four approaches for promoting chronotherapy-based drug treatment in clinical practice: targeting drug development and regulatory authorities; education about chronotherapy; drug information for both health professionals and consumers; and a chronotherapy network.KEYWORDS: circadian rhythmchronopharmacologychronotherapyclinical practicepharmacokinetics AcknowledgmentsWe thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.Article highlights Chronopharmacology is an approach that allows knowledge about circadian rhythm to be incorporated into pharmacotherapy. Chronotherapy, which is the clinical application of chronopharmacology, could be beneficial in the treatment of many diseases.The influence of circadian rhythm on drug disposition is described and examples of chronotherapy in clinical practice are provided.We propose four approaches for promoting chronotherapy-based drug treatment in clinical practice.Declaration of interestThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.Reviewer disclosuresPeer reviewers on this manuscript have no relevant financial or other relationships to discloseAdditional informationFundingThis paper was not funded.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
番茄酱完成签到 ,获得积分10
14秒前
ycyang完成签到,获得积分20
19秒前
阿尔法贝塔完成签到 ,获得积分10
27秒前
28秒前
lhn完成签到 ,获得积分10
31秒前
坚定向彤发布了新的文献求助50
33秒前
华理附院孙文博完成签到 ,获得积分10
35秒前
隐形曼青应助科研通管家采纳,获得10
38秒前
Bryan应助科研通管家采纳,获得10
38秒前
Bryan应助科研通管家采纳,获得10
38秒前
Bryan应助科研通管家采纳,获得10
38秒前
Bryan应助科研通管家采纳,获得10
38秒前
居里姐姐完成签到 ,获得积分10
47秒前
niko完成签到 ,获得积分10
49秒前
我和你完成签到 ,获得积分10
54秒前
sowhat完成签到 ,获得积分10
59秒前
大猪完成签到 ,获得积分10
1分钟前
威武灵阳完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
MrChew完成签到 ,获得积分10
1分钟前
涛1完成签到 ,获得积分10
1分钟前
guhao完成签到 ,获得积分10
1分钟前
zx完成签到 ,获得积分10
1分钟前
知行者完成签到 ,获得积分10
1分钟前
arsenal完成签到 ,获得积分10
1分钟前
中恐完成签到,获得积分0
2分钟前
hyxu678完成签到,获得积分10
2分钟前
calphen完成签到 ,获得积分10
2分钟前
916应助lixian采纳,获得10
2分钟前
长情箴完成签到 ,获得积分10
2分钟前
mark33442完成签到,获得积分10
2分钟前
热心的飞风完成签到 ,获得积分10
2分钟前
荆华完成签到,获得积分10
2分钟前
树苗白菜钱完成签到,获得积分10
2分钟前
2分钟前
D-L@rabbit完成签到 ,获得积分10
2分钟前
兴奋的小笼包完成签到,获得积分10
2分钟前
土豆晴完成签到 ,获得积分10
2分钟前
jibenkun完成签到,获得积分10
2分钟前
量子星尘发布了新的文献求助10
2分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976735
求助须知:如何正确求助?哪些是违规求助? 3520831
关于积分的说明 11204848
捐赠科研通 3257602
什么是DOI,文献DOI怎么找? 1798800
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806648