19F‐Labeled Probes for Recognition‐Enabled Chromatographic 19F NMR

Abstract The NMR technique is among the most powerful analytical methods for molecular structural elucidation, process monitoring, and mechanistic investigations; however, the direct analysis of complex real‐world samples is often hampered by crowded NMR spectra that are difficult to interpret. The combination of fluorine chemistry and supramolecular interactions leads to a unique detection method named recognition‐enabled chromatographic (REC) 19 F NMR, where interactions between analytes and 19 F‐labeled probes are transduced into chromatogram‐like 19 F NMR signals of discrete chemical shifts. In this account, we summarize our endeavor to develop novel 19 F‐labeled probes tailored for separation‐free multicomponent analysis. The strategies to achieve chiral discrimination, sensitivity enhancement, and automated analyte identification will be covered. The account will also provide a detailed discussion of the underlying principles for the design of molecular probes for REC 19 F NMR where appropriate.