Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis.

医学 内科学 相对风险 心房颤动 心力衰竭 糖尿病 安慰剂 随机对照试验 冲程(发动机) 荟萃分析 心脏病学
作者
Hang Long Li,Gregory Y.H. Lip,Qi Feng,Yue Fei,Yi Kei Tse,Mei zhen Wu,Qing Wen Ren,Hung-Fat Tse,Bernard M.Y. Cheung,Kai-Hang Yiu
出处
期刊:Cardiovascular Diabetology [BioMed Central]
被引量:37
标识
DOI:10.1186/s12933-021-01293-8
摘要

Cardiac arrhythmias are associated with poorer outcomes in patients with heart failure (HF), diabetes mellitus (DM), and chronic kidney disease (CKD). Previous studies have shown inconsistent conclusions regarding the association between sodium-glucose cotransporter 2 inhibitors (SGLT2i) and the risk of developing arrhythmias. This study aims to investigate the association of SGLT2i treatment with arrhythmia outcomes in clinical trials of patients with HF, DM, or CKD.MEDLINE, EMBASE, and ClinicalTrials.gov were searched from inception up to 27 August 2020. Randomized controlled trials that randomized patients with DM, CKD, or HF to SGLT2i or placebo were included. The outcomes of interest include atrial fibrillation (AF), embolic stroke, atrial flutter (AFL), AF/AFL, ventricular tachycardia (VT), and cardiac arrest. Relative risks (RRs) and 95% confidence intervals (CI) were pooled using a random-effects model.Out of 4,532 citations, 22 trials with altogether 52,115 patients were included (mean age 63.2 years; 33,747 [64.8%] of participants were men). SGLT2i were associated with a lower risk of AF (RR 0.82, 95% CI 0.70-0.96), embolic stroke (RR 0.32, 95% CI 0.12-0.85), AF/AFL (RR 0.82, 95% CI 0.71-0.95), and VT (RR 0.73, 95% CI 0.53-0.99), while the risk reductions in AFL (RR 0.83, 95% CI 0.58-1.17) and cardiac arrest (RR 0.83, 95% CI 0.61-1.14) did not reach statistical significance. The associations appeared to be consistent across different baseline conditions (DM vs CKD vs HF; atherosclerotic cardiovascular disease [ASCVD] vs no ASCVD) and the SGLT2i used.SGLT2i reduced the risk of cardiac arrhythmias. Our study provides further evidence for recommending the use of SGLT2i in patients with DM, CKD, and HF. Further research is needed to fully elucidate the mechanism by which SGLT2i protect against arrhythmias.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
Zachtack完成签到,获得积分10
1秒前
1秒前
后会无期完成签到,获得积分10
2秒前
炒鸡小将发布了新的文献求助10
2秒前
2秒前
法外狂徒唐老鸭完成签到 ,获得积分10
3秒前
香蕉觅云应助maying0318采纳,获得10
4秒前
4秒前
无花果应助碧蓝碧凡采纳,获得10
5秒前
_hhhjhhh完成签到,获得积分10
5秒前
Leo完成签到,获得积分10
6秒前
7秒前
淘气科研发布了新的文献求助10
7秒前
小徐801完成签到,获得积分10
7秒前
8秒前
8秒前
wwk完成签到,获得积分10
8秒前
光亮不平完成签到,获得积分10
9秒前
llwxx完成签到,获得积分10
9秒前
梁大海发布了新的文献求助10
9秒前
甜蜜的楷瑞应助_hhhjhhh采纳,获得10
10秒前
諵十一完成签到,获得积分10
10秒前
zqingqing完成签到,获得积分10
11秒前
yize完成签到,获得积分10
12秒前
13秒前
13秒前
崔悦欣发布了新的文献求助10
13秒前
谨慎的擎宇完成签到,获得积分10
14秒前
Thomas完成签到,获得积分10
15秒前
小白鞋完成签到 ,获得积分10
15秒前
maying0318发布了新的文献求助10
17秒前
宣以晴完成签到,获得积分10
17秒前
Nnn完成签到,获得积分10
18秒前
baby完成签到,获得积分10
21秒前
123完成签到,获得积分10
21秒前
22秒前
学术牛马完成签到,获得积分10
22秒前
sl发布了新的文献求助10
24秒前
完美的鹤完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029