适体
指数富集配体系统进化
纳米技术
寡核苷酸
2019年冠状病毒病(COVID-19)
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
计算生物学
计算机科学
病毒学
DNA
生物
核糖核酸
医学
分子生物学
材料科学
传染病(医学专业)
遗传学
基因
疾病
病理
作者
Cong Han,Qian Li,Haishuo Ji,Wenping Xing,Limin Zhang,Liyun Zhang
标识
DOI:10.1002/asia.202100242
摘要
Abstract Aptamers are short single‐stranded DNA or RNA oligonucleotides selected by the technique of systematic evolution of ligands by exponential enrichment (SELEX). Aptamers have been demonstrated to bind various targets from small‐molecule to cells or even tissues in the way of antibodies. Thus, they are called chemical antibodies. We summarize and evaluate recent developments in aptamer‐based sensors (for short aptasensors) for virus detection in this review. These aptasensors are mainly classified into optical and electronic aptasensors based on the type of transducer. Nowadays, the smartphone has become the most widely used mobile device with billions of users worldwide. Considering the ongoing COVID‐19 outbreak, smartphone‐based aptasensors for a portable and point‐of‐care test (POCT) of COVID‐19 detection will be of great importance in the future.
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