免疫抑制
生殖系统
生殖毒性
男科
生物
纤维化
腹腔注射
Mercury(编程语言)
精子
怀孕
垃圾箱
内分泌学
生理学
内科学
毒理
毒性
医学
免疫学
生态学
程序设计语言
遗传学
计算机科学
作者
Siyu Li,Bing Han,Pengfei Wu,Qingyue Yang,Xiaoqiao Wang,Jiayi Li,Yuge Liao,Ning Deng,Huijie Jiang,Zhigang Zhang
摘要
Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through the food chain. However, it is unknown that the detailed mechanism of reproductive disorder induced by inorganic mercury in male mice to date. This study investigated the toxicological effect of mercuric chloride (HgCl2 ) exposure on reproductive system in male mice. Male Kunming mice received normal saline daily or HgCl2 (3 mg/kg bodyweight) by intraperitoneal injection for a week. The reproductive function was evaluated, and the HgCl2 exposure induced the decline of sperm quality, pregnancy rate, mean litter size, and survival rate. Notably, we firstly found the HgCl2 -induced immunosuppression and fibrosis in mice testis according to the results of RNA sequencing. Collectively, these findings demonstrate that HgCl2 exposure disrupts the reproductive system and induces testicular immunosuppression and fibrosis via inhibition of the CD74 signaling pathway in male mice.
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