Multiple Neurodevelopmental Mechanisms of Schizophrenia in Patient-Derived Cerebral Organoids

Schizophrenia is presumed to be defined by neurodevelopmental pathology during fetal development. However, because of an inability to ethically study developing human neural tissue in utero, early arising schizophrenia neuropathology remains unknown and thus undefined. Resolving this matter would revolutionize our understanding of schizophrenia development, and define when pioneer neuropathology of schizophrenia actually begins.