亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

MRI-based (MAST) score accurately identifies patients with NASH and significant fibrosis

医学 脂肪性肝炎 脂肪肝 纤维化 内科学 胃肠病学 肝活检 队列 瞬态弹性成像 弹性成像 磁共振弹性成像 人口 活检 疾病 肝纤维化 放射科 超声波 环境卫生
作者
Mazen Noureddin,Emily Truong,Jeffrey Gornbein,Rola Saouaf,Maha Guindi,Tsuyoshi Todo,Nabil Noureddin,Ju Dong Yang,Stephen A. Harrison,Naim Alkhouri
出处
期刊:Journal of Hepatology [Elsevier BV]
卷期号:76 (4): 781-787 被引量:134
标识
DOI:10.1016/j.jhep.2021.11.012
摘要

Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with fibrotic non-alcoholic steatohepatitis (Fibro-NASH) is a clinical priority, as these patients are at the highest risk of disease progression and will benefit most from pharmacologic treatment. MRI-based proton density fat fraction (MRI-PDFF) and MR elastography (MRE) can risk-stratify patients with NAFLD by assessing steatosis and fibrosis, respectively. We developed a highly specific MRI-based score to identify patients with Fibro-NASH.This analysis included derivation (n = 103) and validation (n = 244) cohorts of patients who underwent MRI, liver biopsy, transient elastography, and laboratory testing for NAFLD from 2016-2020 in 2 tertiary care centers. To identify Fibro-NASH, a formula was developed based on MRI-PDFF, MRE, and a third variable with highest balanced accuracy per logistic regression. The MRI-aspartate aminotransferase (MAST) score was created and compared to NAFLD fibrosis (NFS), Fibrosis-4 (FIB-4), and FibroScan-aspartate aminotransferase (FAST) scores.The MAST score demonstrated high performance and discrimination in the validation cohort (AUC 0.93; 95% CI 0.88-0.97). In the validation cohorts, the 90% specificity cut-off of 0.242 corresponded to a sensitivity of 75.0%, positive predictive value (PPV) of 50.0% and negative predictive value (NPV) of 96.5%, whereas the 90% sensitivity cut-off of 0.165 corresponded to a specificity of 72.2%, PPV of 29.4%, and NPV of 98.1%. Compared to NFS and FIB-4, MAST resulted in fewer patients having indeterminate scores and an overall higher AUC. Compared to FAST, MAST exhibited a higher AUC and overall better discrimination.The MAST score is an accurate, MRI-serum-based score that outperforms previous scores in non-invasively identifying patients at higher risk of Fibro-NASH.Identifying patients with non-alcoholic steatohepatitis and significant fibrosis - who need treatment and are at risk of clinical liver-related outcomes - is a clinical priority. We developed a more accurate score using MRI-based technologies and a laboratory blood test (aspartate aminotransferase) that outperforms previous non-invasive scores for the identification of patients at higher risk of liver disease progression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
顺心蜜粉发布了新的文献求助200
1秒前
7秒前
Djnsbj发布了新的文献求助10
15秒前
19秒前
breeze发布了新的文献求助10
24秒前
我是老大应助科研通管家采纳,获得10
25秒前
Daisy完成签到,获得积分10
36秒前
58秒前
量子星尘发布了新的文献求助150
1分钟前
自由的无色完成签到 ,获得积分10
1分钟前
ZHH完成签到,获得积分10
1分钟前
1分钟前
feiying发布了新的文献求助10
1分钟前
滕皓轩完成签到 ,获得积分20
1分钟前
feiying完成签到,获得积分10
1分钟前
CodeCraft应助Djnsbj采纳,获得10
1分钟前
2分钟前
2分钟前
2分钟前
量子星尘发布了新的文献求助10
2分钟前
KSung完成签到 ,获得积分10
2分钟前
2分钟前
临河盗龙发布了新的文献求助30
3分钟前
临河盗龙完成签到,获得积分20
3分钟前
zhanglq完成签到,获得积分10
3分钟前
3分钟前
studystudy完成签到,获得积分10
3分钟前
激动的似狮完成签到,获得积分10
3分钟前
自律发布了新的文献求助10
3分钟前
NexusExplorer应助fukase采纳,获得10
3分钟前
自律完成签到,获得积分10
3分钟前
量子星尘发布了新的文献求助10
4分钟前
4分钟前
fukase完成签到,获得积分10
4分钟前
fukase发布了新的文献求助10
4分钟前
jiangjiang完成签到 ,获得积分10
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
tsttst完成签到,获得积分10
4分钟前
4分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976665
求助须知:如何正确求助?哪些是违规求助? 3520756
关于积分的说明 11204743
捐赠科研通 3257502
什么是DOI,文献DOI怎么找? 1798733
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806629