Increased Nerve Growth Factor Serum Levels in Top Athletes

医学 运动员 内科学 物理疗法 物理医学与康复
作者
Matteo Bonini,Daniela Piergili Fioretti,Vittorio Sargentini,Stefano Del Giacco,Monica Rinaldi,C. Tranquilli,С. Бонини
出处
期刊:Clinical Journal of Sport Medicine [Ovid Technologies (Wolters Kluwer)]
卷期号:23 (3): 228-231 被引量:21
标识
DOI:10.1097/jsm.0b013e31827ee6d5
摘要

Objective: The nerve growth factor (NGF) is the main neurotrophin, which, besides being an important growth factor for nerves, plays an important role as a mediator of inflammation. Nerve growth factor has been shown to increase in relation to stress stimuli and in allergic diseases in humans as well as after physical exercise in animal models. This study aims at evaluating NGF serum levels in top athletes, a population sample in which allergic and neuro–immune diseases are reported with a significantly increased prevalence. Design: Observational, cross-sectional, multicenter study. Setting: Institutional, tertiary care. Participants: Ninety-six Italian pre-Olympic athletes (44 allergic and 52 nonallergic) and 49 matched controls selected within the Italian National Olympic delegation (n = 435). Independent Variables: Nerve growth factor serum levels determined through an enzyme-linked immunosorbent assay. Main Outcome Measures: Parametric or nonparametric tests were used for comparing NGF serum levels among different study groups depending on value distributions. Results: Nerve growth factor serum levels were significantly higher in athletes than in controls independently from the presence of allergy. Nerve growth factor mean values were 368.3 ± 776.3 pg/mL in the sample of athletes and 174.1 ± 483.7 pg/mL in the control group (P < 0.001). Conclusions: This is the first study showing that intense and prolonged physical exercise is associated with an increase of NGF serum levels in athletes. Whether the increased NGF production might be linked to the prevalent Th2 response observed in allergic diseases and after physical exercise and whether it might be related to the patophysiology of neuro–immune disorders as such amyotrophic lateral sclerosis, reported with a higher prevalence in athletes, should deserve further investigations.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
OeO完成签到 ,获得积分10
刚刚
qingli完成签到,获得积分10
刚刚
无奈青发布了新的文献求助10
1秒前
精灵夜雨完成签到,获得积分10
1秒前
飞常美丽发布了新的文献求助30
1秒前
1秒前
今天看文献了吗完成签到,获得积分10
2秒前
2秒前
zxf完成签到,获得积分20
2秒前
哈呵嚯嘿呀完成签到,获得积分10
2秒前
123发布了新的文献求助10
2秒前
罐罐儿应助杨仔采纳,获得10
2秒前
2秒前
Dawn发布了新的文献求助10
3秒前
西灵壹发布了新的文献求助10
3秒前
4秒前
木南楠a完成签到,获得积分10
4秒前
SciGPT应助familiar_people采纳,获得10
4秒前
kimihee完成签到,获得积分10
4秒前
残月初升完成签到,获得积分10
5秒前
娃哈哈完成签到,获得积分20
5秒前
完美世界应助火山采纳,获得10
5秒前
亲爱的安德烈完成签到,获得积分10
5秒前
月月发布了新的文献求助50
5秒前
情怀应助小鲨鱼采纳,获得10
5秒前
6秒前
LYN发布了新的文献求助10
6秒前
wu完成签到,获得积分10
6秒前
7秒前
7秒前
Tyche发布了新的文献求助10
7秒前
娃哈哈发布了新的文献求助10
8秒前
九月完成签到,获得积分10
8秒前
wu发布了新的文献求助10
9秒前
852应助爱听歌雪旋采纳,获得10
10秒前
Vivi发布了新的文献求助10
10秒前
10秒前
Rena发布了新的文献求助10
11秒前
sky发布了新的文献求助10
11秒前
天天快乐应助123采纳,获得10
11秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245464
求助须知:如何正确求助?哪些是违规求助? 2889085
关于积分的说明 8256869
捐赠科研通 2557437
什么是DOI,文献DOI怎么找? 1386114
科研通“疑难数据库(出版商)”最低求助积分说明 650285
邀请新用户注册赠送积分活动 626541